Effects of moderate-intensity aerobic training on cardiac structure and function in type 2 mellitus diabetic rats: Based on echocardiography and speckle tracking

IF 2.9 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Journal of diabetes and its complications Pub Date : 2024-10-22 DOI:10.1016/j.jdiacomp.2024.108896

Chunyan Huang , Shengnan Lin , Zhiwei Yan , Weiliang Yu , Dan Wang , Yiping Liu

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引用次数: 0

Abstract

Purpose

The present study aimed to evaluate the cardiac function changes using Layer-specific Speckle-tracking echocardiography (LS-STE) induced by Moderate-intensity aerobic training (MIAT) in Type 2 diabetes mellitus (T2DM) rats.

Methods

Twenty-six rats were divided into four groups: the Control group (Con), the Training control group (CT), the T2DM group (DM), and the T2DM training group (DT). The CT and DT groups underwent an 8 weeks MIAT. Cardiac structure and function were evaluated by echocardiography and LS-STE.

Results

Compared with the Con group, left atrial diameter (LAD), left ventricular end-diastolic diameter(LVEDD), relation wall thickness (RWT), and left ventricular mass (LVM) were significantly higher, and the endo-, mid-, and epi-longitudinal strain (LS), global radial strain (GRS), and endo- and mid-circumferential strain (CS) were significantly lower in DM rats (all p < 0.05). The endo-, mid-, and epi-LS, GRS, endo- and mid-CS were increased in DT rats compared with DM rats (all p < 0.05). Compared with Con rats, CT rats had a significant increase in LVEDD and LVM (all p < 0.05), meanwhile myocardial strains had no significant differences (all p > 0.05).

Conclusion

LS-STE was a sensitive method to assess subclinical myocardial changes in T2DM rats. MIAT had the benefit of reversing cardiac systolic subclinical dysfunction in T2DM rats.

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中等强度有氧训练对 2 型糖尿病大鼠心脏结构和功能的影响：基于超声心动图和斑点追踪技术。

目的：本研究旨在利用层特异性斑点追踪超声心动图（LS-STE）评估中等强度有氧训练（MIAT）诱导 2 型糖尿病（T2DM）大鼠心功能的变化：将 26 只大鼠分为四组：对照组（Con）、训练对照组（CT）、T2DM 组（DM）和 T2DM 训练组（DT）。CT 组和 DT 组接受为期 8 周的 MIAT。通过超声心动图和 LS-STE 评估心脏结构和功能：结果：与 Con 组相比，DM 大鼠的左心房直径 (LAD)、左心室舒张末期直径 (LVEDD)、室壁厚度 (RWT) 和左心室质量 (LVM) 明显升高，内、中、外纵向应变 (LS)、全桡侧应变 (GRS) 和内中、外周应变 (CS) 明显降低（均 p 0.05）：结论：LS-STE 是评估 T2DM 大鼠亚临床心肌变化的灵敏方法。MIAT具有逆转T2DM大鼠心脏收缩亚临床功能障碍的益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of diabetes and its complications 医学-内分泌学与代谢

CiteScore

5.90

自引率

3.30%

发文量

153

审稿时长

16 days

期刊介绍： Journal of Diabetes and Its Complications (JDC) is a journal for health care practitioners and researchers, that publishes original research about the pathogenesis, diagnosis and management of diabetes mellitus and its complications. JDC also publishes articles on physiological and molecular aspects of glucose homeostasis. The primary purpose of JDC is to act as a source of information usable by diabetes practitioners and researchers to increase their knowledge about mechanisms of diabetes and complications development, and promote better management of people with diabetes who are at risk for those complications. Manuscripts submitted to JDC can report any aspect of basic, translational or clinical research as well as epidemiology. Topics can range broadly from early prediabetes to late-stage complicated diabetes. Topics relevant to basic/translational reports include pancreatic islet dysfunction and insulin resistance, altered adipose tissue function in diabetes, altered neuronal control of glucose homeostasis and mechanisms of drug action. Topics relevant to diabetic complications include diabetic retinopathy, neuropathy and nephropathy; peripheral vascular disease and coronary heart disease; gastrointestinal disorders, renal failure and impotence; and hypertension and hyperlipidemia.