Sex differences in recovery from postoperative sarcopenia during adjuvant CAPOX therapy for colorectal cancer.

IF 2.7 3区 医学 Q3 ONCOLOGY
Hiroaki Nozawa, Shinya Abe, Kentaro Abe, Yumi Yokota, Shunsuke Hori, Mitsutaka Yakabe, Kazuhito Sasaki, Shigenobu Emoto, Yuichiro Yokoyama, Hirofumi Sonoda, Koji Murono, Hiroyuki Matsuzaki, Yuzo Nagai, Takahide Shinagawa, Masahiro Akishita, Soichiro Ishihara
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引用次数: 0

Abstract

Background: Women are predisposed to develop intolerance to cancer chemotherapy. Sarcopenia and chemotherapy are mutually related. Women are generally intolerable to chemotherapeutics such as 5-fluorouracil. Although adjuvant oxaliplatin-based chemotherapy, e.g. CAPOX is commonly used to treat colorectal cancer, its effects on patients in terms of sarcopenia and sex remain unknown. We investigated sex disparities in the impacts of CAPOX on body composition in this study.

Methods: We conducted a prospective study on diagnostic metrics used for sarcopenia in colorectal cancer patients receiving adjuvant CAPOX. Evaluations of the nutritional status by the Mini-Nutritional Assessment (MNA), gait speed, grip strength, skeletal muscle mass, fat mass, and bone mineral content using a body composition analyzer were performed in the first, fourth, and eighth cycles of CAPOX (first, second, and third measurements, respectively).

Results: Among 80 eligible patients, 61 completed four CAPOX cycles. The median differences in MNA, gait, grip strength, muscle mass, fat mass, and bone mineral content between the first and second measurements for men (n = 35) and women (n = 26) were + 10.5% and + 2.9% (p = 0.067), + 4.5% and - 2.6% (p = 0.16), + 1.8% and + 2.8% (p = 0.66), + 2.7% and + 1.3% (p = 0.021), + 4.5% and + 3.5% (p = 0.59), and + 3.3% and + 0.0% (p = 0.006), There were no sex differences in comparisons of the above metrics between the first and third measurements in 34 patients who completed eight CAPOX cycles (19 wen and 15 women).

Conclusions: Early cycles of adjuvant CAPOX may have a negative impact on the postoperative recovery of several metrics for diagnosing sarcopenia in women.

结直肠癌术后 CAPOX 辅助治疗期间肌少症恢复情况的性别差异。
背景:女性容易对癌症化疗产生不耐受。肌肉疏松症与化疗互为因果。女性通常无法耐受 5-氟尿嘧啶等化疗药物。虽然以奥沙利铂为基础的辅助化疗(如 CAPOX)常用于治疗结直肠癌,但其对患者肌肉疏松症和性别的影响仍不为人知。本研究调查了 CAPOX 对身体组成影响的性别差异:我们对接受 CAPOX 辅助治疗的结直肠癌患者的肌少症诊断指标进行了前瞻性研究。在 CAPOX 的第一、第四和第八个周期(分别为第一、第二和第三次测量),我们使用小型营养评估(MNA)、步速、握力、骨骼肌质量、脂肪量和骨矿物质含量分析仪对患者的营养状况、步速、握力、骨骼肌质量、脂肪量和骨矿物质含量进行了评估:在80名符合条件的患者中,61人完成了四个CAPOX周期。男性(35 人)和女性(26 人)的 MNA、步态、握力、肌肉质量、脂肪质量和骨矿物质含量在第一次和第二次测量之间的中位差异分别为 + 10.5% 和 + 2.9% (p = 0.067)、+ 4.5% 和 - 2.6% (p = 0.16)、+ 1.8% 和 + 2.8% (p = 0.66)、+ 2.在完成 8 个 CAPOX 周期的 34 名患者(19 名女性和 15 名男性)中,第一次和第三次测量的上述指标比较没有性别差异:结论:早期辅助 CAPOX 周期可能会对女性术后肌少症诊断指标的恢复产生负面影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.00
自引率
2.80%
发文量
577
审稿时长
2 months
期刊介绍: The "Journal of Cancer Research and Clinical Oncology" publishes significant and up-to-date articles within the fields of experimental and clinical oncology. The journal, which is chiefly devoted to Original papers, also includes Reviews as well as Editorials and Guest editorials on current, controversial topics. The section Letters to the editors provides a forum for a rapid exchange of comments and information concerning previously published papers and topics of current interest. Meeting reports provide current information on the latest results presented at important congresses. The following fields are covered: carcinogenesis - etiology, mechanisms; molecular biology; recent developments in tumor therapy; general diagnosis; laboratory diagnosis; diagnostic and experimental pathology; oncologic surgery; and epidemiology.
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