Role of Sam68 in different types of cancer (Review).

IF 5.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
International journal of molecular medicine Pub Date : 2025-01-01 Epub Date: 2024-10-25 DOI:10.3892/ijmm.2024.5444
Carlos Jiménez-Cortegana, Flora Sánchez-Jiménez, Luis De La Cruz-Merino, Víctor Sánchez-Margalet
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引用次数: 0

Abstract

Src‑associated in mitosis 68 kDa protein (Sam68) is a protein encoded by the heteronuclear ribonucleoprotein particle K homology (KH) single domain‑containing, RNA‑binding, signal transduction‑associated protein 1 (known as KHDRBS1) gene in humans. This protein contains binding sites for critical components in a variety of cellular processes, including the regulation of gene expression, RNA processing and cell signaling. Thus, Sam68 may play a role in a variety of diseases, including cancer. Sam68 has been widely demonstrated to participate in tumor cell proliferation, progression and metastasis to be involved in the regulation of cancer stem cell self‑renewal. Based on the body of evidence available, Sam68 emerges as a promising target for this disease. The objectives of the present included summarizing the role of Sam68 in cancer murine models and cancer patients, unraveling the molecular mechanisms underlying its oncogenic potential and discussing the effectiveness of antitumor agents in reducing the malignant effects of Sam68 during tumorigenesis.

Sam68 在不同类型癌症中的作用(综述)。
有丝分裂中的 Src-associated 68 kDa 蛋白(Sam68)是一种由人类异核核糖核蛋白颗粒 K 同源(KH)单域、RNA 结合、信号转导相关蛋白 1(又称 KHDRBS1)基因编码的蛋白质。这种蛋白含有多种细胞过程中关键成分的结合位点,包括基因表达调控、RNA 处理和细胞信号传导。因此,Sam68 可能在包括癌症在内的多种疾病中发挥作用。Sam68 已被广泛证实参与肿瘤细胞的增殖、发展和转移,并参与调控癌症干细胞的自我更新。根据现有的证据,Sam68 是一种很有前景的疾病靶点。本研究的目的包括总结 Sam68 在癌症小鼠模型和癌症患者中的作用,揭示其致癌潜能的分子机制,并讨论抗肿瘤药物在肿瘤发生过程中减少 Sam68 恶性作用的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International journal of molecular medicine
International journal of molecular medicine 医学-医学:研究与实验
CiteScore
12.30
自引率
0.00%
发文量
124
审稿时长
3 months
期刊介绍: The main aim of Spandidos Publications is to facilitate scientific communication in a clear, concise and objective manner, while striving to provide prompt publication of original works of high quality. The journals largely concentrate on molecular and experimental medicine, oncology, clinical and experimental cancer treatment and biomedical research. All journals published by Spandidos Publications Ltd. maintain the highest standards of quality, and the members of their Editorial Boards are world-renowned scientists.
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