The Advances in the Development of Epigenetic Modifications Therapeutic Drugs Delivery Systems.

IF 6.6 2区医学 Q1 NANOSCIENCE & NANOTECHNOLOGY

International Journal of Nanomedicine Pub Date : 2024-10-19 eCollection Date: 2024-01-01 DOI:10.2147/IJN.S480095

Tingyi Li, Yanwei Chen, Shuai Li

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Abstract

Epigenetic dysregulation can significantly trigger the onset and progression of various diseases, epigenetic therapy is a new treatment strategy by changing DNA methylation, histone modification, N6-methyladenosine, chromatin modification and other epigenetic modifications to regulate gene expression levels for therapeutic purposes. However, small-molecule epigenetic drugs face challenges in disease treatment, such as lack of selectivity, limited therapeutic efficacy, and insufficient safety. Nanomedicine delivery systems offer significant advantages in addressing these issues by enhancing drug targeting, improving bioavailability, and reducing nonspecific distribution. This help minimize side effects while increasing both therapeutic effectiveness and safety of epigenetic drugs. In this review, we focus on the mechanism and role of epigenetic regulatory factors in diseases, as well as the challenges faced by small molecule inhibitors in treatment strategies, especially the research advancements in epigenetic drug delivery systems, review and discuss the therapeutic potential and challenges of using nanotechnology to develop epigenetic drug delivery systems.

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表观遗传修饰治疗药物输送系统的开发进展》。

表观遗传失调可显著诱发各种疾病的发生和发展，表观遗传学疗法是一种新的治疗策略，通过改变DNA甲基化、组蛋白修饰、N6-甲基腺苷、染色质修饰等表观遗传修饰来调节基因表达水平，达到治疗目的。然而，小分子表观遗传药物在疾病治疗中面临着选择性不足、疗效有限、安全性不够等挑战。纳米药物传输系统通过增强药物靶向性、提高生物利用度和减少非特异性分布，在解决这些问题方面具有显著优势。这有助于最大限度地减少副作用，同时提高表观遗传药物的疗效和安全性。在这篇综述中，我们将重点探讨表观遗传调控因子在疾病中的机制和作用，以及小分子抑制剂在治疗策略中面临的挑战，特别是表观遗传给药系统的研究进展，回顾和讨论利用纳米技术开发表观遗传给药系统的治疗潜力和挑战。

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来源期刊

International Journal of Nanomedicine NANOSCIENCE & NANOTECHNOLOGY-PHARMACOLOGY & PHARMACY

CiteScore

14.40

自引率

3.80%

发文量

511

审稿时长

1.4 months

期刊介绍： The International Journal of Nanomedicine is a globally recognized journal that focuses on the applications of nanotechnology in the biomedical field. It is a peer-reviewed and open-access publication that covers diverse aspects of this rapidly evolving research area. With its strong emphasis on the clinical potential of nanoparticles in disease diagnostics, prevention, and treatment, the journal aims to showcase cutting-edge research and development in the field. Starting from now, the International Journal of Nanomedicine will not accept meta-analyses for publication.