The Neglected Suppressor of Cytokine Signalling (SOCS): SOCS4-7.

IF 4.5 2区 医学 Q2 CELL BIOLOGY
Juber Herrera-Uribe, Orla Convery, Daniah ALmohammadi, Fabienne Ingrid Weinberg, Nigel J Stevenson
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引用次数: 0

Abstract

SOCS proteins are essential for the regulation of oncogenic, anti-pathogenic, and proinflammatory signalling cascades, including the JAK/STAT and NF-kB pathways, where they act as negative feedback regulators. Given their powerful role in a broad spectrum of biological processes, it is surprising that the functions of many SOCS proteins have not been widely explored. While the mechanisms of action of CIS, SOCS1-3 are well-documented, information regarding SOCS4-7 remains limited. However, recent studies have begun to elucidate the regulatory functions of these proteins during infection and disease, such as influenza infection, cancer and diabetes. Therefore, this review aims to describe and discuss studies detailing our current understanding of SOCS4-7, painting a clearer picture of the biological processes these regulatory proteins maintain. Indeed, our review highlights important evidence proving that all SOCS play a role in biological processes that are essential for normal immunological homeostasis, clearance of infection and avoidance of disease. Understanding how SOCS proteins interact with other proteins or how they are dysregulated in disease is likely to provide valuable insights for advancing therapeutic approaches.

被忽视的细胞因子信号抑制因子(SOCS):SOCS4-7。
SOCS 蛋白对于调节致癌、抗病和促炎信号级联(包括 JAK/STAT 和 NF-kB 通路)至关重要,它们在其中起着负反馈调节器的作用。鉴于 SOCS 蛋白在广泛的生物过程中发挥的强大作用,许多 SOCS 蛋白的功能尚未得到广泛探索,这一点令人惊讶。虽然 CIS、SOCS1-3 的作用机制已被详细记录,但有关 SOCS4-7 的信息仍然有限。不过,最近的研究已开始阐明这些蛋白在感染和疾病(如流感感染、癌症和糖尿病)过程中的调控功能。因此,本综述旨在描述和讨论有关研究,详细说明我们目前对 SOCS4-7 的了解,从而更清晰地描绘出这些调控蛋白所维持的生物过程。事实上,我们的综述强调了一些重要证据,证明所有 SOCS 都在正常免疫平衡、清除感染和避免疾病所必需的生物过程中发挥作用。了解 SOCS 蛋白如何与其他蛋白相互作用或在疾病中如何失调,可能会为推进治疗方法提供有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Inflammation
Inflammation 医学-免疫学
CiteScore
9.70
自引率
0.00%
发文量
168
审稿时长
3.0 months
期刊介绍: Inflammation publishes the latest international advances in experimental and clinical research on the physiology, biochemistry, cell biology, and pharmacology of inflammation. Contributions include full-length scientific reports, short definitive articles, and papers from meetings and symposia proceedings. The journal''s coverage includes acute and chronic inflammation; mediators of inflammation; mechanisms of tissue injury and cytotoxicity; pharmacology of inflammation; and clinical studies of inflammation and its modification.
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