Biocompatible Hydrogel Coating on Silicone Rubber with Improved Antifouling and Durable Lubricious Properties.

IF 5 3区化学 Q1 POLYMER SCIENCE

Gels Pub Date : 2024-10-11 DOI:10.3390/gels10100647

Shuai Gao, Zheng Liu, Wei Zeng, Yunfeng Zhang, Fanjun Zhang, Dimeng Wu, Yunbing Wang

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引用次数: 0

Abstract

Silicone rubber is widely used in various medical applications. However, silicone rubber is prone to biofouling due to their affinity for lipids and has a high friction coefficient, which can significantly impact their efficacy and performance used as medical devices. Thus, the development of hydrogels with antifouling and lubricious abilities for the modification of silicone rubber is in high demand. We herein prepared a variety of hydrogel coatings mainly based on polyvinylpyrrolidone (PVP) and poly (ethylene glycol) diacrylate (PEGDA). We modified the silicone rubber using the prepared hydrogel coatings and cured it using a heating method. Then, we characterized its surface and evaluated the antifouling property, lubricious property, cytotoxicity, sensitization, and vaginal irritation. The results of water contact angle (WCA), protein adsorption, and friction coefficient indicated the success of the modification of the silicone rubber, leading to a significant decrease in the corresponding test values. Meanwhile, the results of cytotoxicity, sensitization, and vaginal irritation tests showed that the hydrogel coating-modified silicone rubbers have an excellent biocompatibility. This study describes how the silicone rubber could be modified with a biocompatible hydrogel coating. The hydrogel coating-modified silicone rubbers have improved antifouling and durable lubricious properties.

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硅橡胶上的生物相容性水凝胶涂层具有更好的防污和持久润滑性能。

硅橡胶广泛应用于各种医疗领域。然而，由于硅橡胶与脂质的亲和性和高摩擦系数，硅橡胶容易产生生物污垢，这会严重影响其作为医疗器械的功效和性能。因此，开发具有防污和润滑能力的水凝胶来改性硅橡胶的需求量很大。在此，我们主要基于聚乙烯吡咯烷酮（PVP）和聚（乙二醇）二丙烯酸酯（PEGDA）制备了多种水凝胶涂层。我们使用制备的水凝胶涂层对硅橡胶进行改性，并使用加热方法对其进行固化。然后，我们对其表面进行了表征，并评估了其防污性、润滑性、细胞毒性、致敏性和阴道刺激性。水接触角（WCA）、蛋白质吸附和摩擦系数的结果表明，硅橡胶改性成功，使相应的测试值显著下降。同时，细胞毒性、致敏性和阴道刺激性测试结果表明，水凝胶涂层改性硅橡胶具有良好的生物相容性。本研究介绍了如何用生物相容性水凝胶涂层改性硅橡胶。水凝胶涂层改性硅橡胶具有更好的防污和持久润滑性能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gels POLYMER SCIENCE-

CiteScore

4.70

自引率

19.60%

发文量

707

审稿时长

11 weeks

期刊介绍： The journal Gels (ISSN 2310-2861) is an international, open access journal on physical (supramolecular) and chemical gel-based materials. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the maximum length of the papers, and full experimental details must be provided so that the results can be reproduced. Short communications, full research papers and review papers are accepted formats for the preparation of the manuscripts. Gels aims to serve as a reference journal with a focus on gel materials for researchers working in both academia and industry. Therefore, papers demonstrating practical applications of these materials are particularly welcome. Occasionally, invited contributions (i.e., original research and review articles) on emerging issues and high-tech applications of gels are published as special issues.