Synthesis Techniques and Biomedical Applications of Cyclodextrin Metal-Organic Frameworks.

IF 3.5 4区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current medicinal chemistry Pub Date : 2024-10-21 DOI:10.2174/0109298673328126241003092124

Divyesh Kankva, Parixit Prajapati, Gehan M Elossaily, Bhupendra Prajapati

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引用次数: 0

Abstract

Cyclodextrin Metal-Organic Frameworks (CD MOFs) represent an innovative class of materials with remarkable properties and a broad range of applications. This review provides a comprehensive overview of the synthesis techniques, structural characterization, and diverse applications of CD-MOFs. By combining cyclodextrins (CDs) with metal-organic frameworks (MOFs), CD-MOFs are developed with enhanced functionality. The synthesis methods, including various metal sources, coordination modes, and post-synthesis modifications, are discussed alongside advanced structural characterization techniques like X-ray crystallography and spectroscopic methods. The unique characteristics of CD-MOFs, such as high specific surface area, tunable porosity, and customizable chemical structure, make them exceptional candidates for applications in gas adsorption, drug delivery, catalysis, sensing, and environmental remediation. Notably, CD-MOFs show significant promise as nanocarriers in drug delivery systems, offering improved therapeutic outcomes due to their efficient encapsulation and controlled release capabilities. The review highlights recent advancements and underscores the potential impact of CD-MOFs in driving future innovations across various scientific fields.

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环糊精金属有机框架的合成技术和生物医学应用。

环糊精金属有机框架（CD MOFs）是一类性能卓越、应用广泛的创新材料。本综述全面概述了 CD-MOFs 的合成技术、结构特征和各种应用。通过将环糊精（CD）与金属有机框架（MOFs）相结合，CD-MOFs 被开发出具有更强的功能性。在讨论合成方法（包括各种金属源、配位模式和合成后修饰）的同时，还讨论了先进的结构表征技术，如 X 射线晶体学和光谱学方法。CD-MOFs 具有高比表面积、可调孔隙率和可定制化学结构等独特特性，使其成为气体吸附、药物输送、催化、传感和环境修复等应用领域的理想候选材料。值得注意的是，CD-MOFs 作为纳米载体在药物输送系统中大有可为，其高效的封装和控释能力可改善治疗效果。本综述重点介绍了最新进展，并强调了 CD-MOFs 在推动各科学领域未来创新方面的潜在影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current medicinal chemistry 医学-生化与分子生物学

CiteScore

8.60

自引率

2.40%

发文量

468

审稿时长

3 months

期刊介绍： Aims & Scope Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.