Evolving Treatment Landscape for Advanced Esophageal and Gastroesophageal Junction Adenocarcinoma.

IF 4.7 2区医学 Q1 ONCOLOGY

Current Oncology Reports Pub Date : 2024-11-01 Epub Date: 2024-10-23 DOI:10.1007/s11912-024-01607-5

Margaret C Wheless, Margaret Comer, Michael K Gibson

引用次数: 0

Abstract

Purpose of review: This review highlights advances and recent changes in the treatment paradigm for advanced esophageal adenocarcinoma (EAC) and gastroesophageal junction adenocarcinoma (GEJAC).

Recent findings: Chemotherapy remains the backbone of treatment for advanced EAC/GEJAC. New targets/agents include immunotherapy, HER-2, claudin18.2, and FGFR2b, with various mechanisms (CAR-T, bispecific mAB, ADCs) altering the treatment landscape against these targets. The approaches to these targets may act together, in sequence, and even synergistically to improve outcomes. Herein, we review the state of the field, including highlighting ongoing clinical trials and additional emerging agents and approaches.

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晚期食管癌和胃食管交界腺癌的治疗形势不断变化。

综述目的：本综述重点介绍晚期食管腺癌（EAC）和胃食管连接部腺癌（GEJAC）治疗模式的进展和最新变化：化疗仍是治疗晚期食管腺癌/胃食管交界腺癌的主要手段。新靶点/试剂包括免疫疗法、HER-2、claudin18.2和FGFR2b，各种机制（CAR-T、双特异性mAB、ADCs）改变了针对这些靶点的治疗格局。针对这些靶点的治疗方法可以同时、依次甚至协同发挥作用，从而改善疗效。在此，我们将回顾该领域的现状，包括重点介绍正在进行的临床试验以及其他新兴药物和方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Oncology Reports ONCOLOGY-

CiteScore

8.50

自引率

0.00%

发文量

187

审稿时长

6-12 weeks

期刊介绍： This journal aims to review the most important, recently published clinical findings in the field of oncology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by cancer. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as cancer prevention, leukemia, melanoma, neuro-oncology, and palliative medicine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.