Effect of a reduced arterial axial pre-stretch ratio during aging on the cardiac output and cerebral blood flow in the healthy elders

IF 4.9 2区医学 Q1 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS

Computer methods and programs in biomedicine Pub Date : 2024-10-18 DOI:10.1016/j.cmpb.2024.108468

Heming Cheng , Dongfang Ding , Jifeng Dai , Gen Li , Ke Zhang , Jianyun Li , Liuchuang Wei , Xue Zhang , Jie Hou

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引用次数: 0

Abstract

Background and objective

It is an indisputable physiological phenomenon that the arterial axial pre-stretch ratio (AAPSR) decreases with age, but little attention has been paid to the effect of this reduction on chronic diseases during aging.

Methods

Here we reported an experimental method to simulate arteries aging, developed a fluid-structure interaction model with the effect of AAPSR changes, and compared it with the anatomy data and structural parameters of the human thoracic aorta.

Results

We showed that with the process of aging, the decrease of AAPSR leads to a decline of arterial elasticity, a decrease of arterial elastic strain energy, which weakens the ability to promote blood circulation, the corresponding decrease in cardiac output (CO) and cerebral blood flow (CBF) causes distal organ and body tissue ischemia, which is one of the main causes of increased blood pressure and decreased cerebral perfusion in the elderly.

Conclusions

Thus, reduced AAPSR is the one of main manifestation of arteries aging and has an important impact on hypertension and hypoperfusion of the brain in the process of human aging. The research contributes to a better understanding of the physiological and pathological mechanisms of aging-related diseases.

查看原文本刊更多论文

衰老过程中动脉轴向预拉伸率降低对健康老人心输出量和脑血流量的影响。

背景和目的：方法：本文报道了一种模拟动脉衰老的实验方法，建立了具有AAPSR变化效应的流固相互作用模型，并将其与人体胸主动脉的解剖数据和结构参数进行了比较：结果表明，随着年龄的增长，AAPSR的降低导致动脉弹性下降，动脉弹性应变能降低，从而减弱了促进血液循环的能力，相应的心输出量（CO）和脑血流量（CBF）的降低引起远端器官和机体组织缺血，这是老年人血压升高和脑灌注减少的主要原因之一：因此，AAPSR 降低是动脉老化的主要表现之一，对人体衰老过程中的高血压和脑灌注不足有重要影响。该研究有助于更好地理解衰老相关疾病的生理和病理机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Computer methods and programs in biomedicine 工程技术-工程：生物医学

CiteScore

12.30

自引率

6.60%

发文量

601

审稿时长

135 days

期刊介绍： To encourage the development of formal computing methods, and their application in biomedical research and medical practice, by illustration of fundamental principles in biomedical informatics research; to stimulate basic research into application software design; to report the state of research of biomedical information processing projects; to report new computer methodologies applied in biomedical areas; the eventual distribution of demonstrable software to avoid duplication of effort; to provide a forum for discussion and improvement of existing software; to optimize contact between national organizations and regional user groups by promoting an international exchange of information on formal methods, standards and software in biomedicine. Computer Methods and Programs in Biomedicine covers computing methodology and software systems derived from computing science for implementation in all aspects of biomedical research and medical practice. It is designed to serve: biochemists; biologists; geneticists; immunologists; neuroscientists; pharmacologists; toxicologists; clinicians; epidemiologists; psychiatrists; psychologists; cardiologists; chemists; (radio)physicists; computer scientists; programmers and systems analysts; biomedical, clinical, electrical and other engineers; teachers of medical informatics and users of educational software.