Agreement between Mycobacterium tuberculosis antigen-based skin test and interferon-gamma release assay in elderly individuals aged ≥65 years in China.

IF 10.9 1区医学 Q1 INFECTIOUS DISEASES

Clinical Microbiology and Infection Pub Date : 2024-10-23 DOI:10.1016/j.cmi.2024.10.016

Yijun He, Lingyu Shen, Jiang Du, Xuefang Cao, Bin Zhang, Dakuan Wang, Boxuan Feng, Zihan Li, Yuanzhi Di, Juanjuan Huang, Tonglei Guo, Jianguo Liang, Jiaoxia Yan, Zisen Liu, Qi Jin, Weitao Duan, Henan Xin, Lei Gao

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引用次数: 0

Abstract

Objectives: To determine the agreement of Mycobacterium tuberculosis (MTB) antigen-based skin test (TBST) with interferon-gamma release assay (IGRA) in the elderly individuals aged ≥65 years beyond instruction for use in China.

Methods: Based on the baseline survey of a randomized controlled trial with the objective of exploring suitable regimens for tuberculosis(TB) preventive treatment, MTB infection was tested using TBST and IGRA in parallel in rural residents aged 50-70 years using a cross-sectional study design.

Results: A total of 21 219 participants with both TBST and IGRA results were included in this analysis. The concordance between TBST and IGRA was 89.4% (95% CI, 89.0-89.8%) with a kappa coefficient of 0.61 (95% CI, 0.60-0.62). In those aged ≥65 years, the concordance was 86.5% (95% CI, 85.6-87.4%) with a kappa coefficient of 0.55 (95% CI, 0.52-0.58). 21.2% (35/165) of the participants with indeterminate IGRA results were TBST positive, and nine of them were aged ≥65 years.

Discussion: The consistent agreement between TBST and IGRA in individuals aged ≥65 years suggests that TBST has the potential to be used in the elderly with age beyond instruction for use in China. The respective diagnostic performance of each test will be analysed when the longitudinal data on incident TB is obtained in the future.

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中国≥65 岁老年人结核分枝杆菌抗原皮试与干扰素-γ 释放测定之间的一致性。

目的方法：根据随机对照试验的基线调查，以探索合适的结核病预防治疗方案为目标，在中国≥65 岁的老年人中同时使用结核分枝杆菌抗原皮试（TBST）和γ干扰素释放试验（IGRA）检测 MTB 感染情况：方法：在随机对照试验基线调查的基础上，以探索合适的结核病预防治疗方案为目标，采用横断面研究设计，对 50-70 岁的农村居民同时使用 TBST 和 IGRA 检测 MTB 感染情况：本次分析共纳入了 21219 名同时获得 TBST 和 IGRA 结果的参与者。TBST 和 IGRA 的一致性为 89.4%（95%CI：89.0 - 89.8%），卡帕系数为 0.61（95%CI：0.60 - 0.62）。在年龄≥ 65 岁的人群中，一致性为 86.5%（95%CI：85.6 - 87.4%），卡帕系数为 0.55（95%CI：0.52 - 0.58）。IGRA结果不确定的参与者中有21.2%（35/165）为TBST阳性，其中9人年龄≥65岁：结论：TBST 和 IGRA 在年龄≥ 65 岁的人群中的一致性表明，TBST 有可能用于年龄超出中国使用说明的老年人。将来获得结核病发病的纵向数据后，将对每种检测方法各自的诊断性能进行分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Microbiology and Infection 医学-传染病学

CiteScore

25.30

自引率

2.10%

发文量

441

审稿时长

2-4 weeks

期刊介绍： Clinical Microbiology and Infection (CMI) is a monthly journal published by the European Society of Clinical Microbiology and Infectious Diseases. It focuses on peer-reviewed papers covering basic and applied research in microbiology, infectious diseases, virology, parasitology, immunology, and epidemiology as they relate to therapy and diagnostics.