A New Diterpenoid Alkaloid with Antimicrobial Activity from Aconitum brachypodum Diels.

IF 2.3 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry & Biodiversity Pub Date : 2024-10-23 DOI:10.1002/cbdv.202402400

Yan Shu, Shu Yao, Yan Luo, Hua-Juan Yang, Jia-Peng Wang, Le Cai

引用次数: 0

Abstract

A new C₂₀-denudatine-type diterpenoid alkaloid (DA) 11S-aconicarnine D (1) and fifteen known DAs were isolated from the lateral roots of Aconitum brachypodum Diels. Their structures were identified on the basis of extensive spectroscopic analyses, NMR calculations and DP4+ analysis. Compounds 1 and 4 exhibited antimicrobial activity against Alternaria panax with MICs of 2.00 and 8.00 μg/mL (Nystatin, 1.00 μg/mL), respectively.

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来自 Aconitum brachypodum Diels 的具有抗菌活性的新二萜生物碱。

从 Aconitum brachypodum Diels 的侧根中分离出了一种新的 C20-去氢型二萜生物碱（DA）11S-aconicarnine D (1) 和 15 种已知的 DAs。通过大量的光谱分析、核磁共振计算和 DP4+ 分析，确定了它们的结构。对化合物 1 的抗菌活性进行了评估，结果表明化合物 1 对三叶互生菌（Alternaria panax）和茄镰孢菌（Fusarium solani）具有很强的抗菌活性，其 MIC 值分别为 2.00 和 16.00 μg/mL（Nystatin，1.00 μg/mL）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.