Glycosphingolipids in Cardiovascular Disease: Insights from Molecular Mechanisms and Heart Failure Models.

IF 4.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomolecules Pub Date : 2024-10-08 DOI:10.3390/biom14101265

Sarah Huang, Karima Abutaleb, Sumita Mishra

引用次数: 0

Abstract

This review explores the crucial role of glycosphingolipids (GSLs) in the context of cardiovascular diseases (CVDs), focusing on their biosynthesis, metabolic pathways, and implications for clinical outcomes. GSLs are pivotal in regulating a myriad of cellular functions that are essential for heart health and disease progression. Highlighting findings from both human cohorts and animal models, this review emphasizes the potential of GSLs as biomarkers and therapeutic targets. We advocate for more detailed mechanistic studies to deepen our understanding of GSL functions in cardiovascular health, which could lead to innovative strategies for diagnosis, treatment, and personalized medicine in cardiovascular care.

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心血管疾病中的糖磷脂：从分子机制和心力衰竭模型中获得的启示。

这篇综述探讨了糖磷脂（GSLs）在心血管疾病（CVDs）中的关键作用，重点是糖磷脂的生物合成、代谢途径以及对临床结果的影响。糖脂磷脂在调节对心脏健康和疾病进展至关重要的多种细胞功能方面起着关键作用。本综述重点介绍了人类队列和动物模型的研究结果，强调了 GSL 作为生物标志物和治疗靶点的潜力。我们主张进行更详细的机理研究，以加深我们对 GSL 在心血管健康中的功能的了解，这将为心血管护理中的诊断、治疗和个性化医疗带来创新策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.40

自引率

3.60%

发文量

1640

审稿时长

18.28 days

期刊介绍： Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.