Chronically Increased Levels of Circulating Insulin Secondary to Insulin Resistance: A Silent Killer.

IF 3.9 3区 工程技术 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Serafino Fazio, Paolo Bellavite, Flora Affuso
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引用次数: 0

Abstract

Despite all the progress made by science in the prevention and treatment of cardiovascular diseases and cancers, these are still the main reasons for hospitalizations and death in the Western world. Among the possible causes of this situation, disorders related to hyperinsulinemia and insulin resistance (Hyperin/IR) are still little-known topics. An analysis of the literature shows that this condition is a multiple risk factor for type 2 diabetes, cardiovascular diseases, cellular senescence and cancer, and neurodegenerative diseases. Hyperin/IR is progressively increasing worldwide, and its prevalence has now exceeded 50% of the general population and in overweight children. Asymptomatic or poorly symptomatic, it can last for many years before manifesting itself as diabetes, cardiovascular disease, neoplasm, cognitive deficit, or dementia, therefore leading to enormous social and healthcare costs. For these reasons, a screening plan for this pathology should be implemented for the purpose of identifying people with Hyperin/IR and promptly starting them on preventive treatment.

继发于胰岛素抵抗的循环胰岛素水平长期升高:无声的杀手
尽管科学界在预防和治疗心血管疾病和癌症方面取得了长足的进步,但在西方国家,这些疾病仍然是住院和死亡的主要原因。在造成这种情况的可能原因中,与高胰岛素血症和胰岛素抵抗(Hyperin/IR)有关的疾病仍然是鲜为人知的话题。文献分析表明,这种情况是导致 2 型糖尿病、心血管疾病、细胞衰老和癌症以及神经退行性疾病的多重风险因素。高胰岛素血症/高胰岛素红细胞增多症在全球范围内呈上升趋势,目前在普通人群和超重儿童中的发病率已超过 50%。由于无症状或症状不明显,它可能会持续多年才表现为糖尿病、心血管疾病、肿瘤、认知障碍或痴呆症,从而导致巨大的社会和医疗成本。因此,应实施该病症的筛查计划,以识别高血脂/高胆固醇血症患者,并及时对他们进行预防性治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomedicines
Biomedicines Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
5.20
自引率
8.50%
发文量
2823
审稿时长
8 weeks
期刊介绍: Biomedicines (ISSN 2227-9059; CODEN: BIOMID) is an international, scientific, open access journal on biomedicines published quarterly online by MDPI.
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