Optimization and Bioactive Evaluation of Bifurcaria bifurcata Antioxidant-Rich Extracts for Functional Food and Pharmaceutical Applications.

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Aurora Silva, Maria Carpena, Lucia Cassani, Clara Grosso, Paula Garcia-Oliveira, Cristina Delerue-Matos, Jesus Simal-Gandara, Maria Fatima Barroso, Miguel A Prieto
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Abstract

In recent years, consumers have been increasingly interested in natural, healthier, functional foods, with a focus on sea-based products such as algae. Bifurcaria bifurcata (BB) is a macroalga that belongs to the Phaeophyceae class. These brown algae are recognized as the source of bioactive molecules of great interest to the pharmaceutical and nutraceutical industries. The present work applied response surface methodology to optimize the microwave-assisted extraction of the poorly studied algae. The optimization variables were time, pressure, and solvent composition (ethanol/water) and the response parameters selected were yield, total phenolic and flavonoid content, and the antioxidant profile by evaluating DPPH•+, ABTS•+ scavenging activity, and β-carotene discoloration capacity. The results obtained reveal remarkable bioactivity of the crude extract of BB with positive results as an antioxidant and antimicrobial agent. Furthermore, the BB extract's capacity to inhibit enzymes related to neurodegenerative diseases and its anti-inflammatory and anti-proliferation activity open the possibility of future food or pharmaceutical applications.

用于功能性食品和药物应用的 Bifurcaria bifurcata 富含抗氧化剂提取物的优化和生物活性评估。
近年来,消费者对天然、健康、功能性食品的兴趣与日俱增,其中以海藻类产品为主。褐藻(Bifurcaria bifurcata,BB)是一种大型藻类,属于辉绿藻门(Phaeophyceae)。这些褐藻被认为是生物活性分子的来源,对制药和保健品行业具有重大意义。本研究应用响应面方法优化了微波辅助萃取这种研究较少的藻类。优化变量为时间、压力和溶剂成分(乙醇/水),选定的响应参数为产量、总酚和类黄酮含量,以及通过评估 DPPH-+、ABTS-+ 清除活性和 β-胡萝卜素褪色能力得出的抗氧化概况。结果表明,BB 粗提取物具有显著的生物活性,可作为抗氧化剂和抗菌剂。此外,BB提取物还具有抑制与神经退行性疾病相关的酶的能力,以及抗炎和抗增殖的活性,这为未来的食品或药品应用提供了可能。
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来源期刊
Antioxidants
Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍: Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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