Microbial metabolite-receptor interactions in the gut microbiome

IF 6.9 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Pamela V. Chang
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引用次数: 0

Abstract

The gut microbiome impacts many physiological processes that greatly influence host health and disease. Metabolites produced by the gut microbiota have emerged as central players in regulating these biological pathways, often through the engagement of specific host receptors. Despite the importance of these microbial metabolites and receptors in human biology, the vast majority of these interactions remain uncharted due to the complex nature of the gut microbiome and the multitude of metabolites that these microbes produce. Here, we highlight recent developments in identifying such host-gut microbiota interactions, including characterization of bioactive metabolites and their mechanisms of action. Understanding these pathways will enable the development of prophylactics and therapeutics for treating many inflammatory diseases that are impacted by the gut microbiota.
肠道微生物群中微生物代谢物与受体之间的相互作用。
肠道微生物群影响着许多生理过程,对宿主的健康和疾病有很大影响。肠道微生物群产生的代谢物已成为调节这些生物通路的核心角色,通常是通过与特定的宿主受体相互作用来实现的。尽管这些微生物代谢物和受体在人类生物学中非常重要,但由于肠道微生物群的复杂性和这些微生物产生的大量代谢物,这些相互作用中的绝大部分仍是未知的。在此,我们将重点介绍在确定这种宿主-肠道微生物群相互作用方面的最新进展,包括生物活性代谢物的特征及其作用机制。了解这些途径将有助于开发预防和治疗药物,以治疗受肠道微生物群影响的多种炎症性疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Opinion in Chemical Biology
Current Opinion in Chemical Biology 生物-生化与分子生物学
CiteScore
13.30
自引率
1.30%
发文量
113
审稿时长
74 days
期刊介绍: COCHBI (Current Opinion in Chemical Biology) is a systematic review journal designed to offer specialists a unique and educational platform. Its goal is to help professionals stay informed about the growing volume of information in the field of Chemical Biology through systematic reviews.
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