Atrasentan in Patients with IgA Nephropathy

IF 96.2 1区医学 Q1 MEDICINE, GENERAL & INTERNAL

New England Journal of Medicine Pub Date : 2024-10-25 DOI:10.1056/nejmoa2409415

Hiddo J.L. Heerspink, Meg Jardine, Donald E. Kohan, Richard A. Lafayette, Adeera Levin, Adrian Liew, Hong Zhang, Amit Lodha, Todd Gray, Yi Wang, Ronny Renfurm, and Jonathan Barrattthe ALIGN Study Investigators*From the Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands (H.J.L.H.), the National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney (M.J.), the Division of Nephrology, University of Utah Health, Salt Lake City (D.E.K.), Stanford University, Stanford, CA (R.A.L.), the University of British Columbia, Vancouver, Canada (A. Levin), Mount Elizabeth Novena Hospital, Singapore (A. Liew), Peking University First Hospital, Beijing (H.Z.), Chinook Therapeutics, Seattle (T.G.), Novartis, East Hanover, NJ (A. Lodha, Y.W.), Novartis, Basel, Switzerland (R.R.), and the University of Leicester, Leicester, United Kingdom (J.B.).

引用次数: 0

Abstract

Patients with IgA nephropathy and severe proteinuria have a high lifetime risk of kidney failure. The efficacy and safety of the selective endothelin type A receptor antagonist atrasentan in reduci...

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阿曲生坦在 IgA 肾病患者中的应用

患有IgA肾病和严重蛋白尿的患者终生面临肾衰竭的高风险。选择性内皮素 A 型受体拮抗剂阿曲生坦（astrasentan）在降低 IgA 肾病患者蛋白尿方面的疗效和安全性，以及对肾衰竭患者的治疗效果都具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

New England Journal of Medicine 医学-医学：内科

CiteScore

145.40

自引率

0.60%

发文量

1839

审稿时长

1 months

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