The role and mechanism of gut-lung axis mediated bidirectional communication in the occurrence and development of chronic obstructive pulmonary disease.

IF 12.2 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gut Microbes Pub Date : 2024-10-24 DOI:10.1080/19490976.2024.2414805

Xiaofan Song,Xina Dou,Jiajing Chang,Xiaonan Zeng,Qinhong Xu,Chunlan Xu

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引用次数: 0

Abstract

The current studies have shown that the occurrence and development of chronic obstructive pulmonary disease (COPD) are closely related to the changes in gut health and its microenvironment, and even some gut diseases have significant clinical correlation with COPD. The dysbiosis of gut microbiota observed in COPD patients also suggests a potential bidirectional interaction between the gut and lung. Communication between the gut and lung may occur through circulating inflammatory cells, gut microbial metabolites, and circulating inflammatory mediators, but the mechanism of bidirectional communication between the gut and lung in COPD is still under study. Therefore, more research is still needed in this area. In this review, we summarize recent clinical studies and animal models on the role of the gut-lung axis in the occurrence and development of COPD and its mechanisms, so as to provide ideas for further research in this field. In addition, we also summarized the negative effects of COPD medication on gut microbiota and the gut microbiota risk factors for COPD and proposed the potential prevention and treatment strategies.

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肠肺轴介导的双向交流在慢性阻塞性肺病的发生和发展中的作用和机制。

目前的研究表明，慢性阻塞性肺病（COPD）的发生和发展与肠道健康及其微环境的变化密切相关，甚至一些肠道疾病与慢性阻塞性肺病有显著的临床相关性。在慢性阻塞性肺病患者中观察到的肠道微生物群失调也表明，肠道和肺之间可能存在双向互动。肠道和肺之间可能通过循环炎症细胞、肠道微生物代谢产物和循环炎症介质进行交流，但慢性阻塞性肺病患者肠道和肺之间的双向交流机制仍在研究之中。因此，这一领域还需要更多的研究。在这篇综述中，我们总结了近期关于肠肺轴在慢性阻塞性肺病发生和发展中的作用及其机制的临床研究和动物模型，从而为这一领域的进一步研究提供思路。此外，我们还总结了慢性阻塞性肺病药物对肠道微生物群的负面影响以及慢性阻塞性肺病的肠道微生物群危险因素，并提出了潜在的预防和治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gut Microbes Medicine-Microbiology (medical)

CiteScore

18.20

自引率

3.30%

发文量

196

审稿时长

10 weeks

期刊介绍： The intestinal microbiota plays a crucial role in human physiology, influencing various aspects of health and disease such as nutrition, obesity, brain function, allergic responses, immunity, inflammatory bowel disease, irritable bowel syndrome, cancer development, cardiac disease, liver disease, and more. Gut Microbes serves as a platform for showcasing and discussing state-of-the-art research related to the microorganisms present in the intestine. The journal emphasizes mechanistic and cause-and-effect studies. Additionally, it has a counterpart, Gut Microbes Reports, which places a greater focus on emerging topics and comparative and incremental studies.