Significance of neurodegeneration and neuroplasticity serum biomarkers in Parkinson’s disease patients treated with subthalamic stimulation

IF 6.7 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2024-10-24 DOI:10.1038/s41531-024-00808-w

Florencia Sanmartino, Fátima Cano-Cano, Raúl Rashid-López, Álvaro Javier Cruz-Gómez, Elena Lozano-Soto, Paloma Macías-García, Francisco L. Sánchez-Fernández, Fernando López-Sosa, Laura Gómez-Jaramillo, Jesús Riqué-Dormido, Francisco Escamilla-Sevilla, Raúl Espinosa-Rosso, Javier J. González-Rosa

引用次数: 0

Abstract

The ability of serum biomarkers to predict the prognosis and response to deep-brain stimulation (DBS) therapy in Parkinson’s disease (PD) patients is promising. Here, we showed that NfL differed between healthy individuals and PD patients and that changes in NfL, GFAP, and BDNF occurred only transiently after DBS surgery. Therefore, subthalamic stimulation does not promote neurodegeneration, and these biomarkers do not serve as clinical improvement endpoints in PD DBS patients.

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接受丘脑下刺激治疗的帕金森病患者的神经变性和神经可塑性血清生物标志物的意义

血清生物标志物能够预测帕金森病（PD）患者的预后和对深部脑刺激（DBS）疗法的反应，这一点很有希望。在这里，我们发现 NfL 在健康人和帕金森病患者之间存在差异，并且 NfL、GFAP 和 BDNF 在 DBS 手术后仅发生短暂变化。因此，丘脑下刺激不会促进神经变性，这些生物标志物也不能作为 PD DBS 患者临床改善的终点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.