Responsive release of guest aqueous droplet in liquid crystal droplet assists the detection of organophosphorus using commercial pregnancy test strip

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical Pub Date : 2024-10-22 DOI:10.1016/j.snb.2024.136777

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引用次数: 0

Abstract

Here, we report a liquid crystal (LC) double-emulsion based system for organophosphorus (OPs) sensing by controllable release of guest aqueous droplets (GADs) cargo. First, double liquid crystal emulsion, water in liquid crystal in water (W/LC/W), with size between 4∼ 20 μm was prepared with GADs loaded at the center of liquid crystal droplet (LCD) through elasticity trap. The LCDs were monodispersed and response sensitively to amphiphilic surfactant with opposite charge. With the capability of ejecting GADs with human chorionic gonadotropin (hCG) as cargo located in LCD to continuous aqueous phase, responsive vehicles are obtained and applied in the repurposing of commercial pregnancy test strip (PTS). With hydrophobic alkyl chain and hydrophilic head, myristoylcholine (Myr) is a good amphiphilic surfactant to trigger the release of hCG, and substrate for the enzymatic hydrolysis of acetylcholine esterase (AChE). Provided with the inhibition effect of OPs to the hydrolysis ability of AChE, OPs correlate positively with the concentration of Myr, thus correlate well with the release of hCG in W/LC/W emulsion. Thus, OPs residue in river or food is readily visualized using commercial PTS.

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液晶液滴中客体水滴的响应释放有助于使用商用妊娠试纸检测有机磷

在此，我们报告了一种基于液晶（LC）双乳液的有机磷（OPs）传感系统，该系统通过可控释放客体水滴（GADs）货物来实现。首先，制备了双液晶乳液，即水包水液晶（W/LC/W），粒径在 4-20 μm 之间，通过弹性阱将 GADs 装载在液晶液滴（LCD）的中心。液晶滴呈单分散状态，对带相反电荷的两亲表面活性剂反应敏感。由于 GADs 能够将液晶滴中作为货物的人绒毛膜促性腺激素（hCG）喷射到连续水相中，因此获得了反应载体，并将其应用于商用妊娠试纸（PTS）的再利用。肉豆蔻酰胆碱（Myr）具有疏水烷基链和亲水头，是一种良好的两亲表面活性剂，可触发 hCG 的释放，也是乙酰胆碱酯酶（AChE）酶水解的底物。由于 OPs 对乙酰胆碱酯酶水解能力的抑制作用，OPs 与 Myr 的浓度呈正相关，从而与 W/LC/W 乳液中 hCG 的释放密切相关。因此，使用商用 PTS 很容易检测出河流或食物中的 OPs 残留。

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来源期刊

Sensors and Actuators B: Chemical 工程技术-电化学

CiteScore

14.60

自引率

11.90%

发文量

1776

审稿时长

3.2 months

期刊介绍： Sensors & Actuators, B: Chemical is an international journal focused on the research and development of chemical transducers. It covers chemical sensors and biosensors, chemical actuators, and analytical microsystems. The journal is interdisciplinary, aiming to publish original works showcasing substantial advancements beyond the current state of the art in these fields, with practical applicability to solving meaningful analytical problems. Review articles are accepted by invitation from an Editor of the journal.