Pregnancy-associated plasma protein-A (PAPP-A) and cardiovascular disease

IF 1.6 4区医学 Q4 CELL BIOLOGY

Growth Hormone & Igf Research Pub Date : 2024-10-09 DOI:10.1016/j.ghir.2024.101625

Cheryl A. Conover

引用次数: 0

Abstract

There is strong evidence that PAPP-A, a local regulator of insulin-like growth factor signaling through proteolytic cleavage of inhibitory binding proteins, is involved in multiple physiological processes associated with cardiovascular disease. This review will describe the various roles of PAPP-A with a focus on atherosclerosis, neointimal hyperplasia, and acute coronary syndrome in animal models and in humans.

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妊娠相关血浆蛋白-A（PAPP-A）与心血管疾病。

有确凿证据表明，PAPP-A 是胰岛素样生长因子信号传导的局部调节因子，它通过蛋白水解作用裂解抑制性结合蛋白，参与多种与心血管疾病相关的生理过程。本综述将介绍 PAPP-A 的各种作用，重点是动物模型和人体中的动脉粥样硬化、新内膜增生和急性冠状动脉综合征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Growth Hormone & Igf Research 医学-内分泌学与代谢

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

57 days

期刊介绍： Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.