Evaluation of hemostatic efficacy and safety of oxidized regenerated cellulose (Pahacel^®) in coronary bypass surgery.

Cirugia y cirujanos Pub Date : 2024-01-01 DOI:10.24875/CIRU.23000535

Hasan A Keskin

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Abstract

Objective: The aim of this study is to evaluate the efficacy and safety of oxidized regenerated cellulose (ORC) in patients who underwent coronary artery bypass grafting (CABG) surgery and to compare the results of patients in whom ORC was used or not used for control of bleeding.

Method: Pre-, intra-, and post-operative demographic and medical parameters of the patients in whom ORC was used or not used were compared. Quantitative data were analyzed with mean and standard deviation. Group differences were assessed with the Mann-Whitney U test.

Results: It was found that the duration of surgery, average numbers of erythrocyte and fresh frozen plasma (FFP) transfusions during surgery, average post-operative FFP transfusion count, duration of intensive care unit stay, and chest tube removal times were lower in the ORC group compared to the control group, and all these differences were statistically significant (p < 0.05 for all of these parameters).

Conclusions: The study successfully demonstrated the effective and safe use of topical ORC in controlling bleeding and preventing oozing during CABG surgeries.

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评估氧化再生纤维素（Pahacel®）在冠状动脉搭桥手术中的止血效果和安全性。

研究目的本研究旨在评估氧化再生纤维素（ORC）对冠状动脉旁路移植手术（CABG）患者的疗效和安全性，并比较使用或未使用氧化再生纤维素控制出血的患者的效果：方法：比较使用或未使用 ORC 的患者术前、术中和术后的人口统计学和医学参数。定量数据以平均值和标准差进行分析。采用 Mann-Whitney U 检验评估组间差异：结果发现，与对照组相比，ORC 组的手术时间、术中输注红细胞和新鲜冰冻血浆（FFP）的平均次数、术后输注 FFP 的平均次数、重症监护室住院时间和胸管拔除时间均较短，且所有这些参数的差异均有统计学意义（P < 0.05）：该研究成功证明了局部 ORC 在 CABG 手术中有效、安全地控制出血和防止渗出。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cirugia y cirujanos

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