Association of the rs12617656 C/T genetic variant of the DPP4 gene with in-stent restenosis in Mexican population: a cohort study.

Archivos de cardiologia de Mexico Pub Date : 2024-10-16 DOI:10.24875/ACM.24000065

Gilberto Vargas-Alarcón, Rosalinda Posadas-Sanchez, Marco A Martínez-Ríos, Hilda Delgadillo-Rodriguez, Victoria López-Olmos, José M Fragoso

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Abstract

Objective: We evaluated whether five (rs12617336, rs12617656, rs1558957, rs3788979, and rs17574) single nucleotide polymorphisms located in the DPP4 gene that have not been sufficiently explored, are candidates to be risk markers of in-stent restenosis.

Methods: The genotypes were determined in 190 patients (60 patients with restenosis and 130 without restenosis) using 5'exonuclease TaqMan assays in accordance with the manufacturer's instructions (Applied Biosystems, Foster City, USA).

Results: The results showed that the CC genotype of the rs12617656 C/T SNP was associated with the risk of development restenosis after coronary stent under the co-dominant, and recessive models (odds ratios [OR] = 3.32, p = 0.0009, and OR = 4.96, p = 0.0008, respectively). In addition, our data showed that the genetic distribution of the rs12617336, rs1558957, rs3788979, and rs17574 SNPs were similar between patients with and without restenosis after coronary stenting. On the other hand, the haplotype analysis showed one haplotype (CTC) associated with restenosis susceptibility (p = 0.006).

Conclusion: Our study demonstrates that the rs12617656 genetic variant of the DPP4 gene is associated with the risk of developing in-stent restenosis in our population.

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墨西哥人群中 DPP4 基因 rs12617656 C/T 遗传变异与支架内再狭窄的关系：一项队列研究。

目的我们评估了位于 DPP4 基因中尚未被充分探讨的五个单核苷酸多态性（rs12617336、rs12617656、rs1558957、rs3788979 和 rs17574）是否可作为支架内再狭窄的风险标记：方法：根据制造商（美国福斯特市应用生物系统公司）的说明，使用 5'exonuclease TaqMan 检测法测定 190 例患者（60 例有再狭窄，130 例无再狭窄）的基因型：结果表明，rs12617656 C/T SNP的CC基因型与冠状动脉支架术后再狭窄的发病风险在共显性和隐性模型下相关（几率比[OR]分别为3.32，P = 0.0009和OR = 4.96，P = 0.0008）。此外，我们的数据还显示，rs12617336、rs1558957、rs3788979 和 rs17574 SNPs 的遗传分布在冠状动脉支架术后出现和未出现再狭窄的患者中相似。另一方面，单倍型分析显示一个单倍型（CTC）与再狭窄易感性相关（p = 0.006）：我们的研究表明，在我国人群中，DPP4 基因的 rs12617656 遗传变异与支架内再狭窄的发病风险有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Archivos de cardiologia de Mexico

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