Non-classical event-related potentials reveal attention network alteration in patients with temporal lobe epilepsy

IF 2.5 3区心理学 Q3 NEUROSCIENCES

International Journal of Psychophysiology Pub Date : 2024-10-19 DOI:10.1016/j.ijpsycho.2024.112456

Yuanyuan Xie , Weina Zhang , Zhongling Wu , Kailing Huang , Yiyuan Geng , Haojun Yang , Li Feng

{"title":"Non-classical event-related potentials reveal attention network alteration in patients with temporal lobe epilepsy","authors":"Yuanyuan Xie , Weina Zhang , Zhongling Wu , Kailing Huang , Yiyuan Geng , Haojun Yang , Li Feng","doi":"10.1016/j.ijpsycho.2024.112456","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>To explore the characteristic changes of multiple ERP components associated with attention impairments in patients with temporal lobe epilepsy (TLE).</div></div><div><h3>Methods</h3><div>A total of 92 patients diagnosed with TLE at Xiangya Hospital during May 2022 and January 2023 and 85 healthy controls were included in this study. Participants were asked to complete attention network test with recording of electroencephalogram.</div></div><div><h3>Results</h3><div>Compared with healthy controls, significant lower amplitudes (cue-related N1, N2 and CNV) and longer latencies (target-related N2) were found in TLE patients. Besides classical components, other components could also reveal the impairments of attention function. Cue-related N1 (<em>p</em> ≤ 0.007) and N2 (<em>p</em> ≤ 0.01) components indicated impaired alerting and orienting network in TLE. And cue-related CNV-E component (<em>p</em> = 0.003) promoted the alerting network was damaged and target-related N2 component (<em>p</em> = 0.008) indicated the executive control network was impaired.</div></div><div><h3>Conclusion</h3><div>These findings consummate the non-classical ERP features of attention impairments in TLE patients.</div></div><div><h3>Significance</h3><div>The above findings have strong clinical guiding significance for early identification and intervention.</div></div>","PeriodicalId":54945,"journal":{"name":"International Journal of Psychophysiology","volume":"206 ","pages":"Article 112456"},"PeriodicalIF":2.5000,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Psychophysiology","FirstCategoryId":"102","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167876024001600","RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

To explore the characteristic changes of multiple ERP components associated with attention impairments in patients with temporal lobe epilepsy (TLE).

Methods

A total of 92 patients diagnosed with TLE at Xiangya Hospital during May 2022 and January 2023 and 85 healthy controls were included in this study. Participants were asked to complete attention network test with recording of electroencephalogram.

Results

Compared with healthy controls, significant lower amplitudes (cue-related N1, N2 and CNV) and longer latencies (target-related N2) were found in TLE patients. Besides classical components, other components could also reveal the impairments of attention function. Cue-related N1 (p ≤ 0.007) and N2 (p ≤ 0.01) components indicated impaired alerting and orienting network in TLE. And cue-related CNV-E component (p = 0.003) promoted the alerting network was damaged and target-related N2 component (p = 0.008) indicated the executive control network was impaired.

Conclusion

These findings consummate the non-classical ERP features of attention impairments in TLE patients.

Significance

The above findings have strong clinical guiding significance for early identification and intervention.

查看原文本刊更多论文

非经典事件相关电位揭示了颞叶癫痫患者注意力网络的改变。

目的探讨与颞叶癫痫（TLE）患者注意力障碍相关的ERP多个成分的特征性变化：方法：选取2022年5月至2023年1月期间在湘雅医院确诊的92名颞叶癫痫患者和85名健康对照者作为研究对象。结果：与健康对照组相比，TLE患者的脑电图振幅明显降低：结果：与健康对照组相比，发现TLE患者的注意网络（与线索相关的N1、N2和CNV）的振幅明显较低，潜伏期（与目标相关的N2）较长。除经典成分外，其他成分也能显示注意力功能的损害。提示相关的N1（p≤0.007）和N2（p≤0.01）成分表明TLE患者的警觉和定向网络受损。与提示相关的CNV-E成分（p = 0.003）表明警觉网络受损，与目标相关的N2成分（p = 0.008）表明执行控制网络受损：这些发现完善了TLE患者注意力障碍的非经典ERP特征：上述发现对早期识别和干预具有很强的临床指导意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Psychophysiology 医学-神经科学

CiteScore

5.40

自引率

10.00%

发文量

177

审稿时长

3-8 weeks

期刊介绍： The International Journal of Psychophysiology is the official journal of the International Organization of Psychophysiology, and provides a respected forum for the publication of high quality original contributions on all aspects of psychophysiology. The journal is interdisciplinary and aims to integrate the neurosciences and behavioral sciences. Empirical, theoretical, and review articles are encouraged in the following areas: • Cerebral psychophysiology: including functional brain mapping and neuroimaging with Event-Related Potentials (ERPs), Positron Emission Tomography (PET), Functional Magnetic Resonance Imaging (fMRI) and Electroencephalographic studies. • Autonomic functions: including bilateral electrodermal activity, pupillometry and blood volume changes. • Cardiovascular Psychophysiology:including studies of blood pressure, cardiac functioning and respiration. • Somatic psychophysiology: including muscle activity, eye movements and eye blinks.