The Influence of Birth Weight, Socio-Economic Status, and Adult Health on Brain Volumes during Ageing.

IF 3.2 3区医学 Q2 CLINICAL NEUROLOGY

Neuroepidemiology Pub Date : 2024-10-14 DOI:10.1159/000541918

Christopher J McNeil, Tina Habota, Anca-Larisa Sandu, Gordon Waiter, Heather Whalley, Alison D Murray

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引用次数: 0

Abstract

Introduction: Greater late-life brain volumes are associated with resilience against dementia. We examined relationships between birth weight, lifelong socio-economic status, and health with late-life brain volumes. We hypothesised that early life factors directly affect late-life brain volumes.

Methods: Adults aged 59-67 y underwent MRI and brain volumes were measured. Birth weight and lifelong health, and socio-economic status were quantified and the principal components of each extracted. Relationships were examined using regression and structural equation analysis.

Results: Birth weight (β = 0.095, p = 0.017) and childhood socio-economic status (β = 0.091, p = 0.033, n = 280) were directly associated with brain volume. Childhood socio-economic status was further associated with grey matter volume (β = 0.04, p = 0.047). Adult health was linked to increased brain volume (β = 0.15, p = 0.003).

Conclusion: Birth weight and childhood socio-economic status are associated with whole and regional brain volume through direct mechanisms. Optimal fetal development, reduced childhood poverty, and good adult health could reduce brain atrophy and delay dementia onset in late-life.

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出生体重、社会经济地位和成人健康对衰老过程中脑容量的影响。

导言：更大的晚年脑容量与抗痴呆能力有关。我们研究了出生体重、终生社会经济地位和健康状况与晚年脑容量之间的关系。我们假设早期生活因素会直接影响晚年脑容量。方法对 59-67 岁的成年人进行核磁共振成像，并测量脑容量。我们对出生体重、终生健康状况和社会经济地位进行了量化，并提取了各自的主要成分。采用回归分析和结构方程分析法研究两者之间的关系。结果出生体重（β=0.095，p=0.017）和童年社会经济状况（β=0.091，p=0.033，n=280）与脑容量直接相关。儿童时期的社会经济地位与灰质体积进一步相关（β=0.04，p=0.047）。成人健康与脑容量的增加有关（β=0.15，p=0.003）。结论出生体重和儿童时期的社会经济地位通过直接机制与全脑和区域脑容量相关。最佳的胎儿发育、减少童年贫困和良好的成人健康状况可减少脑萎缩，延缓晚年痴呆症的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroepidemiology 医学-公共卫生、环境卫生与职业卫生

CiteScore

9.90

自引率

1.80%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Neuroepidemiology'' is the only internationally recognised peer-reviewed periodical devoted to descriptive, analytical and experimental studies in the epidemiology of neurologic disease. The scope of the journal expands the boundaries of traditional clinical neurology by providing new insights regarding the etiology, determinants, distribution, management and prevention of diseases of the nervous system.