Levodopa therapy affects brain functional network dynamics in Parkinson's disease

IF 5.3 2区医学 Q1 CLINICAL NEUROLOGY

Progress in Neuro-Psychopharmacology & Biological Psychiatry Pub Date : 2024-10-12 DOI:10.1016/j.pnpbp.2024.111169

Xiaojin Liu , Yuze Zhang , Yihe Weng , Miao Zhong , Lijuan Wang , Zhenni Gao , Huiqing Hu , Yuhu Zhang , Biao Huang , Ruiwang Huang

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Abstract

Levodopa (L-dopa) therapy is the most effective pharmacological treatment for motor symptoms of Parkinson's disease (PD). However, its effect on brain functional network dynamics is still unclear. Here, we recruited 26 PD patients and 24 healthy controls, and acquired their resting-state functional MRI data before (PD-OFF) and after (PD-ON) receiving 400 mg L-dopa. Using the independent component analysis and the sliding-window approach, we estimated the dynamic functional connectivity (dFC) and examined the effect of L-dopa on the temporal properties of dFC states, the variability of dFC and functional network topological organization. We found that PD-ON showed decreased mean dwell time in sparsely connected State 2 than PD-OFF, the transformation of the dFC state is more frequent and the variability of dFC was decreased within the auditory network and sensorimotor network in PD-ON. Our findings provide new insights to understand the dynamic neural activity induced by L-dopa therapy in PD patients.

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左旋多巴疗法影响帕金森病患者的大脑功能网络动态。

左旋多巴（L-多巴）疗法是治疗帕金森病（PD）运动症状最有效的药物疗法。然而，它对大脑功能网络动态的影响仍不清楚。在此，我们招募了26名帕金森病患者和24名健康对照者，分别在接受400毫克左旋多巴治疗前（PD-OFF）和治疗后（PD-ON）采集了他们的静息态功能磁共振成像数据。我们使用独立成分分析和滑动窗口法估算了动态功能连通性（dFC），并研究了左旋多巴对dFC状态的时间特性、dFC的变异性和功能网络拓扑组织的影响。我们发现，与PD-OFF相比，PD-ON在稀疏连接状态2中的平均停留时间减少了，dFC状态的转换更加频繁，并且在PD-ON的听觉网络和感觉运动网络中dFC的变异性降低了。我们的研究结果为理解左旋多巴治疗诱导的帕金森病患者动态神经活动提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in Neuro-Psychopharmacology & Biological Psychiatry 医学-精神病学

CiteScore

12.00

自引率

1.80%

发文量

153

审稿时长

56 days

期刊介绍： Progress in Neuro-Psychopharmacology & Biological Psychiatry is an international and multidisciplinary journal which aims to ensure the rapid publication of authoritative reviews and research papers dealing with experimental and clinical aspects of neuro-psychopharmacology and biological psychiatry. Issues of the journal are regularly devoted wholly in or in part to a topical subject. Progress in Neuro-Psychopharmacology & Biological Psychiatry does not publish work on the actions of biological extracts unless the pharmacological active molecular substrate and/or specific receptor binding properties of the extract compounds are elucidated.