Effects of High-intensity Continuous Ultrasound on Infrapatellar Fat Pad Stiffness and Gliding in Healthy Participants: A Randomized, Single-blind, Placebo-controlled Crossover Trial

IF 2.4 3区医学 Q2 ACOUSTICS

Ultrasound in Medicine and Biology Pub Date : 2024-10-15 DOI:10.1016/j.ultrasmedbio.2024.09.006

Naoto Ikeda , Taizan Fukaya , Yui Sezaki , Sho Toyoshima , Yuka Yokoi , Katsuyuki Morishita

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引用次数: 0

Abstract

Objective

Ultrasound therapy effectively treats a joint range of motion limitation and pain originating from soft tissue in knee osteoarthritis (OA). Few interventional studies have focused on the infrapatellar fat pad (IFP), and the effects of high-intensity continuous ultrasound (HICUS) on IFP stiffness and gliding have not been investigated. Therefore, we aimed to determine the effects of HICUS on IFP stiffness and gliding.

Methods

This single-blind, randomized, controlled crossover study involved 24 healthy participants. The HICUS and placebo conditions were applied to the knee joint on 2 different days. HICUS was performed (1 MHz, 2.5 W/cm², duty cycle 100%, 5 min) using an ultrasound machine equipped with an applicator and adsorption-type fixed automatic rotation irradiation function. The main outcomes were IFP stiffness and gliding measured at 10 degrees and 120 degrees knee flexion. Gliding was measured as the difference between the patellar-tendon tibial angles at 10 degrees and 120 degrees knee flexion. Measurements were performed before (T1), immediately after (T2), and 15 min after (T3) treatment.

Results

Two-way repeated measures analysis of variance showed a significant interaction of IFP stiffness at 10 degrees knee flexion; post-test results showed that HICUS decreased stiffness at T2 and T3. There was no significant difference at 120 degrees. A significant interaction of gliding was observed under the HICUS condition. Post-tests showed that HICUS significantly improved gliding at T2 and T3.

Conclusion

HICUS is a simple, safe intervention for improving IFP stiffness and gliding in healthy participants, with sustained effects. Further studies are needed to evaluate its efficacy in patients.

查看原文本刊更多论文

高强度连续超声波对健康参与者髌下脂肪垫硬度和滑动的影响：随机、单盲、安慰剂对照交叉试验。

目的超声波疗法能有效治疗膝关节骨关节炎（OA）中关节活动范围受限和软组织引起的疼痛。很少有干预性研究关注髌下脂肪垫（IFP），高强度连续超声（HICUS）对髌下脂肪垫僵硬度和滑动的影响也未进行过研究。因此，我们旨在确定 HICUS 对 IFP 硬度和滑动的影响：这项单盲、随机、对照交叉研究涉及 24 名健康参与者。HICUS和安慰剂分别在两天内作用于膝关节。HICUS使用配备有涂抹器和吸附式固定自动旋转照射功能的超声波机进行（1 MHz，2.5 W/cm²，占空比100%，5分钟）。主要结果是在膝关节屈曲 10 度和 120 度时测量 IFP 的硬度和滑动性。滑动度以膝关节屈曲 10 度和 120 度时髌腱胫骨角度的差值来衡量。测量分别在治疗前（T1）、治疗后（T2）和治疗后 15 分钟（T3）进行：结果：双向重复测量方差分析显示，膝关节屈曲 10 度时的 IFP 僵硬度存在显著的交互作用；后测试结果显示，HICUS 可降低 T2 和 T3 时的僵硬度。120度时没有明显差异。在 HICUS 条件下，滑行与膝关节僵硬度之间存在明显的交互作用。后测结果显示，HICUS 明显改善了 T2 和 T3 的滑行：结论：HICUS 是一种简单、安全的干预措施，可改善健康参与者的 IFP 僵硬度和滑行，并具有持续效果。需要进一步研究以评估其对患者的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ultrasound in Medicine and Biology 医学-核医学

CiteScore

6.20

自引率

6.90%

发文量

325

审稿时长

70 days

期刊介绍： Ultrasound in Medicine and Biology is the official journal of the World Federation for Ultrasound in Medicine and Biology. The journal publishes original contributions that demonstrate a novel application of an existing ultrasound technology in clinical diagnostic, interventional and therapeutic applications, new and improved clinical techniques, the physics, engineering and technology of ultrasound in medicine and biology, and the interactions between ultrasound and biological systems, including bioeffects. Papers that simply utilize standard diagnostic ultrasound as a measuring tool will be considered out of scope. Extended critical reviews of subjects of contemporary interest in the field are also published, in addition to occasional editorial articles, clinical and technical notes, book reviews, letters to the editor and a calendar of forthcoming meetings. It is the aim of the journal fully to meet the information and publication requirements of the clinicians, scientists, engineers and other professionals who constitute the biomedical ultrasonic community.