Efficacy of bone morphogenetic protein in comparison with autogenous bone in regeneration of ameloblastoma bone defects. A systematic review.

IF 1.8 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Medicina Oral Patologia Oral Y Cirugia Bucal Pub Date : 2024-11-01 DOI:10.4317/medoral.26729

W-Y Santos, E Benito-Ramal, J Toledano-Serrabona, M-Á Sánchez-Garcés

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引用次数: 0

Abstract

Background: To evaluate the evidence comparing bone morphogenetic proteins (BMPs) and autogenous bone grafts (ABGs) for regenerating bone defects from ameloblastoma.

Material and methods: An electronic search was performed in PubMed and Scopus from October to December 2023, supplemented by manual searches and review of relevant study reference lists. Cohen's kappa was calculated to assess the interrater reliability between two independent investigators. The methodological quality and risk of bias of the selected articles was assessed using the JBI checklist for case series and the NOS for observational studies.

Results: Nine studies met the inclusion criteria and were selected for the qualitative synthesis. Cohen's kappa (κ) value resulted in 98.21% agreement. A total of 229 participants were included. The BMPs were evaluated in five studies, and four evaluated the ABGs. The BMPs has been tested in 25.76% of the patients, while ABGs were studied in 74.24%. In order to evaluate the final result of regeneration, all the studies based their analysis on postoperative questionnaires, radiographical (CBCT and/or panoramic) and/or clinical examination. The results showed a higher regeneration success rate in the studies where the BMPs was used.

Conclusions: Considering the limitations of the studies and the review, it has been shown that BMPs may yield favorable outcomes in terms of bone regeneration, as compared with ABGs.

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骨形态发生蛋白与自体骨在骨髓母细胞瘤骨缺损再生中的功效比较。系统综述。

背景：评估骨形态发生蛋白（BMPs）和自体骨移植物（ABGs）用于羊膜母细胞瘤骨缺损再生的证据：评估比较骨形态发生蛋白（BMPs）和自体骨移植物（ABGs）再生母细胞瘤骨缺损的证据：从 2023 年 10 月至 12 月，在 PubMed 和 Scopus 上进行了电子检索，并辅以人工检索和查阅相关研究的参考文献列表。计算了科恩卡帕（Cohen's kappa），以评估两名独立调查人员之间的相互可靠性。对所选文章的方法学质量和偏倚风险进行了评估，对病例系列研究采用JBI核对表，对观察性研究采用NOS：结果：9 项研究符合纳入标准，并被选中进行定性综合。Cohen's kappa (κ) 值的一致性为 98.21%。共纳入 229 名参与者。五项研究对 BMPs 进行了评估，四项研究对 ABGs 进行了评估。25.76%的患者接受了 BMPs 测试，74.24%的患者接受了 ABGs 研究。为了评估再生的最终结果，所有研究都根据术后调查问卷、影像学（CBCT 和/或全景）和/或临床检查进行分析。结果显示，使用 BMPs 的研究中再生成功率更高：考虑到研究和综述的局限性，研究结果表明，与 ABGs 相比，BMPs 在骨再生方面可能会产生更好的效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicina Oral Patologia Oral Y Cirugia Bucal DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

3-8 weeks

期刊介绍： 1. Oral Medicine and Pathology: Clinicopathological as well as medical or surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, as well as orofacial neurological disorders, and systemic conditions with an impact on the oral cavity. 2. Oral Surgery: Surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, teeth, implants, oral surgical procedures. Surgical management of diseases affecting head and neck areas. 3. Medically compromised patients in Dentistry: Articles discussing medical problems in Odontology will also be included, with a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients. 4. Implantology 5. Periodontology