Radioligand therapy in the therapeutic strategy for patients with gastro-entero-pancreatic neuroendocrine tumors: a consensus statement from the Italian Association for Neuroendocrine Tumors (Itanet), Italian Association of Nuclear Medicine (AIMN), Italian Society of Endocrinology (SIE), Italian Association of Medical Oncology (AIOM).

IF 5.4 2区医学 Q1 Medicine

Journal of Endocrinological Investigation Pub Date : 2025-01-01 Epub Date: 2024-10-12 DOI:10.1007/s40618-024-02448-6

Francesco Panzuto, Manuela Albertelli, Maria Luisa De Rimini, Francesca Maria Rizzo, Chiara Maria Grana, Mauro Cives, Antongiulio Faggiano, Annibale Versari, Salvatore Tafuto, Nicola Fazio, Annamaria Colao, Federica Scalorbi, Diego Ferone, Saverio Cinieri, Marco Maccauro

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Abstract

Purpose: This paper outlines the consensus of the Italian Association for Neuroendocrine Tumors(Itanet), the Italian Association of Nuclear Medicine (AIMN), the Italian Society of Endocrinology (SIE), and the Italian Association of Medical Oncology (AIOM) on treating neuroendocrine neoplasms (NENs)with radioligand therapy (RLT).

Methods: A list of 10 questions regarding using RLT ingastroenteropancreatic neuroendocrine tumors (GEP-NETs) was addressed after a careful review of theavailable literature. compiling information from the MEDLINE database, augmented with expert opinionsand recommendations, aligns with the latest scientific research and the author's extensive knowledge.The recommendations are evaluated using the GRADE system, showcasing the level of evidence andthe strength of the recommendations.

Results and conclusions: Specifically, this paper focuses on thesubcategories of well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs) thatexpress somatostatin receptors and are considered suitable for RLT, according to internationalguidelines.

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胃肠胰神经内分泌肿瘤患者治疗策略中的放射性配体疗法：意大利神经内分泌肿瘤协会（Itanet）、意大利核医学协会（AIMN）、意大利内分泌学会（SIE）和意大利肿瘤内科协会（AIOM）的共识声明。

目的：本文概述了意大利神经内分泌肿瘤协会（Itanet）、意大利核医学协会（AIMN）、意大利内分泌学会（SIE）和意大利肿瘤内科协会（AIOM）就使用放射性配体疗法（RLT）治疗神经内分泌肿瘤（NENs）达成的共识：在对现有文献进行仔细查阅后，针对有关在胃肠胰神经内分泌肿瘤（GEP-NETs）中使用 RLT 的 10 个问题进行了讨论。本文汇编了 MEDLINE 数据库中的信息，并辅以专家意见和建议，与最新的科学研究和作者的广泛知识保持一致。本文使用 GRADE 系统对建议进行评估，展示了证据水平和建议力度：具体而言，本文重点讨论了根据国际指南，表达体生长抑素受体并被认为适合 RLT 的分化良好的胃肠胰神经内分泌肿瘤（GEP-NET）的子类别。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Endocrinological Investigation ENDOCRINOLOGY & METABOLISM-

CiteScore

8.10

自引率

7.40%

发文量

242

期刊介绍： The Journal of Endocrinological Investigation is a well-established, e-only endocrine journal founded 36 years ago in 1978. It is the official journal of the Italian Society of Endocrinology (SIE), established in 1964. Other Italian societies in the endocrinology and metabolism field are affiliated to the journal: Italian Society of Andrology and Sexual Medicine, Italian Society of Obesity, Italian Society of Pediatric Endocrinology and Diabetology, Clinical Endocrinologists’ Association, Thyroid Association, Endocrine Surgical Units Association, Italian Society of Pharmacology.