Comparison of Nebulized Glycopyrronium with a Combination of Salbutamol and Ipratropium on Ventilatory Parameters in Critically Ill Mechanically Ventilated Patients of Chronic Obstructive Pulmonary Disease: An Observational Study.

IF 1.5 Q3 CRITICAL CARE MEDICINE
Preeti Priya, Soumya S Nath, Virendra Kumar, Suraj Kumar
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引用次数: 0

Abstract

Background: The present study examined the duration of bronchodilation induced by nebulized glycopyrronium bromide (GB) and compared its effectiveness and incidence of any side effects with the combination of salbutamol and ipratropium bromide (SI) in critically ill mechanically ventilated chronic obstructive pulmonary disease (COPD) patients.

Patients and methods: This prospective, observational study was conducted in mechanically ventilated adult patients of COPD (18-75 years). Data of two groups of patients were collected for 12 hours each for three consecutive days after the nebulization - Group I: those who received 25 µg of GB, and Group II: those who received 1.25 mg of levo-salbutamol and 500 µg of ipratropium by nebulization.

Results: A significantly higher number of patients in group II had copious secretions. The mean static compliance was comparable at all time intervals, whereas the mean airway pressure was significantly lower in group II from 15 minutes to 4 hours post-nebulization. In group I, the onset of bronchodilation was 30 minutes on days 1 and 3, and 60 minutes on day 2, whereas, in group II, it was 60 minutes on days 1 and 2 and 30 minutes on day 3. In group I, bronchodilation was 10 hours on day 1 and 12 hours each on days 2 and 3, whereas in group II, bronchodilation was 4 hours on day 1 and 6 hours each on day 2 and 3.

Conclusion: Compared with SI, GB nebulization resulted in lesser respiratory secretions, a longer duration of action in terms of lowered airway resistance, and no adverse effects like hypertension, tachycardia, or desiccation of respiratory secretions.

How to cite this article: Priya P, Nath SS, Kumar V, Kumar S. Comparison of Nebulized Glycopyrronium with a Combination of Salbutamol and Ipratropium on Ventilatory Parameters in Critically Ill Mechanically Ventilated Patients of Chronic Obstructive Pulmonary Disease: An Observational Study. Indian J Crit Care Med 2024;28(10):963-969.

雾化甘草酸铵与沙丁胺醇和异丙托品复方制剂对重症机械通气的慢性阻塞性肺病患者通气参数的影响比较:一项观察性研究。
研究背景本研究对重症机械通气慢性阻塞性肺病(COPD)患者雾化吸入甘草溴铵(GB)诱导支气管扩张的持续时间进行了研究,并比较了其与沙丁胺醇和异丙托溴铵联合用药的效果和副作用发生率:这项前瞻性观察研究的对象是机械通气的慢性阻塞性肺病成年患者(18-75 岁)。收集了两组患者在雾化治疗后连续三天各 12 小时的数据--第一组:接受 25 µg GB 雾化治疗的患者;第二组:接受 1.25 mg 左旋沙丁胺醇和 500 µg 异丙托品雾化治疗的患者:结果:第二组中分泌物较多的患者人数明显较多。所有时间间隔内的平均静态顺应性相当,而在雾化后 15 分钟至 4 小时内,II 组的平均气道压明显较低。在 I 组中,第 1 天和第 3 天的支气管扩张开始时间为 30 分钟,第 2 天为 60 分钟,而在 II 组中,第 1 天和第 2 天为 60 分钟,第 3 天为 30 分钟。在 I 组中,第 1 天的支气管扩张时间为 10 小时,第 2 天和第 3 天各为 12 小时,而在 II 组中,第 1 天的支气管扩张时间为 4 小时,第 2 天和第 3 天各为 6 小时:与 SI 相比,GB 雾化治疗的呼吸道分泌物更少,降低气道阻力的作用时间更长,且无高血压、心动过速或呼吸道分泌物干燥等不良反应:Priya P, Nath SS, Kumar V, Kumar S. Comparison of Nebulized Glycopyrronium with a Combination of Salbutamol and Ipratropium on Ventilatory Parameters in Critically Illically Mechanically Ventilated Patients of Chronic Obstructive Pulmonary Disease:一项观察性研究。Indian J Crit Care Med 2024;28(10):963-969.
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来源期刊
CiteScore
3.50
自引率
10.00%
发文量
299
期刊介绍: Indian Journal of Critical Care Medicine (ISSN 0972-5229) is specialty periodical published under the auspices of Indian Society of Critical Care Medicine. Journal encourages research, education and dissemination of knowledge in the fields of critical and emergency medicine.
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