Twice-yearly lenacapavir: A milestone for HIV prevention in young African women.

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Med Pub Date : 2024-10-11 DOI:10.1016/j.medj.2024.08.008

Silvia Nozza, Antonella Castagna

引用次数: 0

Abstract

The PURPOSE 1 trial¹ demonstrated that after 52 weeks, no cisgender women acquired HIV infection after receiving subcutaneous twice-yearly lenacapavir. HIV incidence with lenacapavir was significantly lower than HIV incidence with daily oral emtricitabine/tenofovir alafenamide (F/TAF) or daily oral emtricitabine/tenofovir disoproxil fumarate (F/TDF). It is the first pre-exposure prophylaxis regimen with 100% efficacy in young women.

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一年两次来那卡韦：非洲年轻女性预防艾滋病的里程碑。

PURPOSE 1试验1表明，52周后，接受一年两次来那卡韦皮下注射的顺性别女性中没有人感染艾滋病毒。来那卡韦的HIV感染率明显低于每日口服恩曲他滨/替诺福韦阿拉非酰胺（F/TAF）或每日口服恩曲他滨/富马酸替诺福韦二吡呋酯（F/TDF）。这是首个对年轻女性具有 100% 有效率的暴露前预防方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Med MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

17.70

自引率

0.60%

发文量

102

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