Unveiling LGR5: Prostate cancer's hidden stem cell and treatment target

IF 2.4 3区医学 Q3 ONCOLOGY

Urologic Oncology-seminars and Original Investigations Pub Date : 2024-10-15 DOI:10.1016/j.urolonc.2024.10.001

Yashvi Patel, Akhilesh Prajapati

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Abstract

Prostate cancer poses a significant risk to the well-being and way of life of countless men, with an increased likelihood of relapse recorded following modern treatment. This highlights the need for innovative approaches, specifically targeting LGR5. This systematic review aims to establish a connection between LGR5 and the various signaling pathways involved in the progression of prostate cancer. LGR5, a gene targeted by Wnt signaling, encodes a receptor protein that serves as a prognostic biomarker for stem cells and indicates the presence of cancer stem cells in colorectal and gastrointestinal cancers. The functions of LGR5 include processes such as cell proliferation, differentiation, and signaling pathways. Any modifications to the LGR5 gene, whether caused by mutations or mechanical stimuli, can lead to the development of treatment-resistant stem cell cancers. This review examines the molecular mechanisms associated with LGR5 and emphasizes methodologies aimed at targeting LGR5 to enhance understanding and promote the development of LGR5-specific therapies.

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揭开 LGR5 的面纱：前列腺癌隐藏的干细胞和治疗靶点。

前列腺癌对无数男性的健康和生活方式构成重大威胁，据记录，现代治疗后复发的可能性增加。这凸显了对创新方法的需求，特别是针对 LGR5 的方法。本系统综述旨在建立 LGR5 与前列腺癌进展所涉及的各种信号通路之间的联系。LGR5是Wnt信号转导的靶向基因，它编码的受体蛋白可作为干细胞的预后生物标志物，并表明结直肠癌和胃肠癌中存在癌症干细胞。LGR5 的功能包括细胞增殖、分化和信号通路等过程。LGR5基因的任何改变，无论是由突变还是机械刺激引起，都可能导致耐药性干细胞癌症的发展。这篇综述探讨了与LGR5相关的分子机制，并强调了旨在靶向LGR5的方法，以加深对LGR5的理解，促进LGR5特异性疗法的开发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Urologic Oncology-seminars and Original Investigations 医学-泌尿学与肾脏学

CiteScore

4.80

自引率

3.70%

发文量

297

审稿时长

7.6 weeks

期刊介绍： Urologic Oncology: Seminars and Original Investigations is the official journal of the Society of Urologic Oncology. The journal publishes practical, timely, and relevant clinical and basic science research articles which address any aspect of urologic oncology. Each issue comprises original research, news and topics, survey articles providing short commentaries on other important articles in the urologic oncology literature, and reviews including an in-depth Seminar examining a specific clinical dilemma. The journal periodically publishes supplement issues devoted to areas of current interest to the urologic oncology community. Articles published are of interest to researchers and the clinicians involved in the practice of urologic oncology including urologists, oncologists, and radiologists.