Risk factors for lung parenchyma hemorrhage and hemoptysis during computed tomography-guided microwave ablation in patients with stage I non-small cell lung cancer: A bicentric retrospective study.

IF 2.3 3区医学 Q3 ONCOLOGY

Thoracic Cancer Pub Date : 2024-11-01 Epub Date: 2024-10-13 DOI:10.1111/1759-7714.15466

Jingshuo Li, Ziqi Zhang, Yuxian Chen, Chunhai Li, Zhigang Wei, Haipeng Jia

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Abstract

Objectives: This study aimed to identify the risk factors for lung parenchyma hemorrhage and hemoptysis during computed tomography-guided microwave ablation (MWA) in patients with stage I non-small cell lung cancer (NSCLC).

Methods: A total of 417 patients from two medical centers were included, of whom 353 were from center 1 and 64 were from center 2. The risk factors for lung parenchyma hemorrhage and hemoptysis were selected by univariable and multivariable logistic analyses in the center 1 dataset. The selected risk factors were validated in the center 2 dataset.

Results: The risk factors for lung parenchyma hemorrhage during MWA were focal blood supplies (odds ratio [OR], 2.602; 95% confidence interval [CI], 1.609-4.210; p < 0.001), near vessels larger than 2 mm (OR, 4.145; 95% CI, 1.963-8.755; p < 0.001), and traversing vessels in the track of ablation (OR, 2.961; 95% CI, 1.492-5.874; p = 0.002). The risk factors for hemoptysis were lung parenchyma hemorrhage (OR, 34.165; 95% CI, 12.255-95.247; p < 0.001), needle track traversing the lung parenchyma by >25 mm (OR, 4.494; 95% CI, 1.833-11.018; p = 0.001), and traversing vessels in the track of ablation (OR, 5.402; 95% CI, 2.269-12.865; p < 0.001).

Conclusions: Focal blood supplies, near vessels larger than 2 mm, and traversing vessels in the track of ablation were independent risk factors for lung parenchyma hemorrhage during MWA. Lung parenchyma hemorrhage, needle track traversing the lung parenchyma by >25 mm, and traversing vessels in the track of ablation were independent risk factors for hemoptysis during MWA.

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I 期非小细胞肺癌患者在计算机断层扫描引导下进行微波消融时发生肺实质出血和咯血的风险因素：一项双中心回顾性研究。

研究目的本研究旨在确定I期非小细胞肺癌（NSCLC）患者在计算机断层扫描引导下进行微波消融（MWA）时发生肺实质出血和咯血的风险因素：方法：共纳入了来自两个医疗中心的 417 名患者，其中 353 人来自中心 1，64 人来自中心 2。在第一中心的数据集中，通过单变量和多变量逻辑分析选出了肺实质出血和咯血的风险因素。选定的风险因素在中心 2 数据集中得到了验证：MWA期间肺实质出血的风险因素是局灶性供血（几率比[OR]，2.602；95%置信区间[CI]，1.609-4.210；P 25 mm（OR，4.494；95% CI，1.833-11.018；P = 0.001），以及消融轨迹中穿越的血管（OR，5.402；95% CI，2.269-12.865；P 结论：MWA期间肺实质出血的风险因素是局灶性供血，以及消融轨迹中穿越的血管（OR，5.402；95% CI，2.269-12.865；P = 0.001）：病灶供血、靠近大于 2 mm 的血管和在消融路径上穿越血管是 MWA 期间肺实质出血的独立风险因素。肺实质出血、针道穿越肺实质大于 25 毫米以及在消融轨道上穿越血管是 MWA 期间发生咯血的独立危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Thoracic Cancer ONCOLOGY-RESPIRATORY SYSTEM

CiteScore

5.20

自引率

3.40%

发文量

439

审稿时长

2 months

期刊介绍： Thoracic Cancer aims to facilitate international collaboration and exchange of comprehensive and cutting-edge information on basic, translational, and applied clinical research in lung cancer, esophageal cancer, mediastinal cancer, breast cancer and other thoracic malignancies. Prevention, treatment and research relevant to Asia-Pacific is a focus area, but submissions from all regions are welcomed. The editors encourage contributions relevant to prevention, general thoracic surgery, medical oncology, radiology, radiation medicine, pathology, basic cancer research, as well as epidemiological and translational studies in thoracic cancer. Thoracic Cancer is the official publication of the Chinese Society of Lung Cancer, International Chinese Society of Thoracic Surgery and is endorsed by the Korean Association for the Study of Lung Cancer and the Hong Kong Cancer Therapy Society. The Journal publishes a range of article types including: Editorials, Invited Reviews, Mini Reviews, Original Articles, Clinical Guidelines, Technological Notes, Imaging in thoracic cancer, Meeting Reports, Case Reports, Letters to the Editor, Commentaries, and Brief Reports.