Balancing act: counteracting adverse drug effects on the microbiome.

IF 14 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Jacobo de la Cuesta-Zuluaga, Patrick Müller, Lisa Maier
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引用次数: 0

Abstract

The human gut microbiome, a community of microbes that plays a crucial role in our wellbeing, is highly adaptable but also vulnerable to drug treatments. This vulnerability can have serious consequences for the host, for example, increasing susceptibility to infections, immune, metabolic, and cognitive disorders. However, the microbiome's adaptability also provides opportunities to prevent, protect, or even reverse drug-induced damage. Recently, several innovative approaches have emerged aimed at minimizing the collateral damage of drugs on the microbiome. Here, we outline these approaches, discuss their applicability in different treatment scenarios, highlight current challenges, and suggest avenues that may lead to an effective protection of the microbiome.

平衡之术:抵消药物对微生物群的不良影响。
人类肠道微生物组是一个微生物群落,对我们的健康起着至关重要的作用,它具有很强的适应性,但也很容易受到药物治疗的影响。这种脆弱性会给宿主带来严重后果,例如,增加感染、免疫、代谢和认知障碍的易感性。然而,微生物组的适应性也为预防、保护甚至逆转药物引起的损害提供了机会。最近,出现了几种创新方法,旨在最大限度地减少药物对微生物组的附带损害。在此,我们概述了这些方法,讨论了它们在不同治疗方案中的适用性,强调了当前面临的挑战,并提出了可能导致有效保护微生物组的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Trends in Microbiology
Trends in Microbiology 生物-生化与分子生物学
CiteScore
25.30
自引率
0.60%
发文量
193
审稿时长
6-12 weeks
期刊介绍: Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.
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