Zhanyong Zhu, Shengzhi Zhou, Sicheng Li, Song Gong, Qi Zhang
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引用次数: 0
Abstract
Wound healing is a complex and orchestrated process that involves hemostasis, inflammation, proliferation, and tissue remodeling. Neutrophil extracellular traps (NETs) are intricate web-like structures released by neutrophils, comprising decondensed chromatin, myeloperoxidase (MPO), and neutrophil elastase (NE), which play vital roles in regulating neutrophil-mediated immune regulation. While NETs contribute to wound healing, excessive activation induced by dysregulated inflammation can hinder the healing process. Understanding the pivotal role of NETs in wound healing and tissue remodeling, as well as their intricate interactions within the wound microenvironment, presents opportunities for innovative wound healing strategies. In this review we discuss the process of NET formation, explore the interactions between NETs and skin cells, and examine therapeutic strategies targeting NETs and drug delivery platforms to accelerate wound healing. Additionally, we discuss current clinical investigations and research challenges towards advancing wound care practices.
伤口愈合是一个复杂而协调的过程，涉及止血、炎症、增殖和组织重塑。中性粒细胞胞外捕获物（NET）是中性粒细胞释放的复杂网状结构，由解聚染色质、髓过氧化物酶（MPO）和中性粒细胞弹性蛋白酶（NE）组成，在调节中性粒细胞介导的免疫调节中发挥着重要作用。虽然嗜中性粒细胞弹性蛋白有助于伤口愈合，但炎症失调引起的过度激活会阻碍伤口愈合过程。了解 NET 在伤口愈合和组织重塑中的关键作用，以及它们在伤口微环境中错综复杂的相互作用，为创新性伤口愈合策略提供了机会。在这篇综述中，我们讨论了 NET 的形成过程，探讨了 NET 与皮肤细胞之间的相互作用，并研究了针对 NET 的治疗策略和加速伤口愈合的给药平台。此外，我们还讨论了当前的临床调查和研究挑战，以推进伤口护理实践。
期刊介绍：
Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research.
The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics.
Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles.
Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.
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