Assessment of uptake of sulphadoxine-pyrimethamine for intermittent preventive treatment among pregnant women in Osun State, Nigeria.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-14 DOI:10.1093/trstmh/trae076

Adebanjo J Adegbola, Ruth M Ogboye, Omotade A Ijarotimi, Akaninyene E Ubom, Bukola A Adesoji, Oluseye O Bolaji

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引用次数: 0

Abstract

Background: About 32 million pregnant women are at the risk of malaria infection yearly in malaria-endemic sub-Saharan Africa. To mitigate the risks associated with malaria in pregnancy, the WHO recommends ≥3 doses of intermittent preventive treatment in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP), covering from the second trimester of pregnancy until delivery.

Methods: This cross-sectional study assessed the uptake and extent of adherence with IPTp-SP among pregnant women in Osun State, Nigeria, from October 2020 to March 2021. Assessment of the uptake was done by extracting information from the validated case report forms. Venous blood samples were obtained to assess the levels of sulphadoxine in plasma through HPLC-UV.

Results: In total, 49.24%, 38.17% and 12.58% of the study participants obtained 1, 2 and ≥3 doses of IPTp-SP, respectively. In assessing the extent of adherence, 46.67% obtained their last dose within 28 d before sample collection. Uptake of IPTp-SP is not associated with gravidity (p=0.603), but is weakly associated with the age of the study participants (p=0.04). The median (IQR) plasma sulphadoxine concentration was 10.6248 (2.8124-27.1242) ug/mL.

Conclusions: Utilisation of the intervention is still very low and adherence appears to be inadequate among the study population, suggesting that more advocacy on the IPTp-SP strategy and the implementation of directly observed therapy is necessary.

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尼日利亚奥孙州孕妇间歇性预防治疗磺胺乙胺嘧啶使用情况评估。

背景：在疟疾流行的撒哈拉以南非洲地区，每年约有 3200 万孕妇面临感染疟疾的风险。为降低妊娠期疟疾的相关风险，世卫组织建议从妊娠后三个月开始至分娩前，使用磺胺乙胺嘧啶（SP）进行≥3次的妊娠期间歇预防性治疗（IPTp）：这项横断面研究评估了尼日利亚奥孙州孕妇在 2020 年 10 月至 2021 年 3 月期间接受 IPTp-SP 治疗的情况和坚持治疗的程度。通过从经过验证的病例报告表中提取信息，对服用情况进行评估。采集静脉血样本，通过高效液相色谱-紫外检测法评估血浆中的磺胺多辛水平：总共有49.24%、38.17%和12.58%的研究参与者分别服用了1、2和≥3剂IPTp-SP。在评估坚持服用的程度时，46.67%的人在样本采集前 28 天内服用了最后一剂。IPTp-SP的摄入量与孕产妇无关（p=0.603），但与研究参与者的年龄有微弱关系（p=0.04）。血浆中磺胺多辛浓度的中位数（IQR）为 10.6248 (2.8124-27.1242) ug/mL：结论：干预措施的利用率仍然很低，研究人群中的依从性似乎不足，这表明有必要对IPTp-SP策略和直接观察疗法的实施进行更多宣传。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.