The probability of implantation metastasis after peripheral lung cancer biopsy.

IF 1.5 4区医学 Q4 ONCOLOGY

Translational cancer research Pub Date : 2024-09-30 Epub Date: 2024-09-27 DOI:10.21037/tcr-24-529

Ziyao Wang, Chuyang Chen, Li Fang, Anbang Wu, Xu Li

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引用次数: 0

Abstract

Background: At present, it is known that there is a possibility of pleural cavity and needle tract implantation metastasis after lung cancer puncture biopsy, but clinicians have not paid attention to this phenomenon, and the probability of occurrence is unknown. In this study, we aimed to study the probability of implantation metastasis after peripheral lung cancer biopsy.

Methods: The intraoperative isolated completely collapsed fresh intact human lung lobes of 30 patients with peripheral lung cancer were taken, and the tumor body was punctured. The pleural pinholes and puncture needle tips were repeatedly rinsed with normal saline respectively. The flushing solution was prepared as inoculum, and then the inoculum was smeared for microscopic examination to find cancer cells. The inoculum was inoculated subcutaneously into nude mice, and then the probability of pleural cavity and needle tract implantation metastasis after lung biopsy was indirectly obtained by obtaining the nude mice tumorigenesis rate.

Results: The tumorigenesis rate of nude mice in the pleural pinholes group was 3.3%, and the tumorigenesis rate of nude mice in the puncture needle tip group was 3.3%.

Conclusions: Patients with lung nodules suspected of being early stage cancer and who are fit for surgical resection may benefit from forgoing lung biopsies to avoid pleural cavity or needle tract seeding with tumor cells.

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外周肺癌活检后种植转移的概率。

背景：目前已知肺癌穿刺活检术后存在胸膜腔和针道种植转移的可能性，但临床医生并未重视这一现象，发生概率不明。本研究旨在研究肺癌穿刺活检术后发生种植转移的概率：方法：取 30 例周围型肺癌患者术中分离的完全塌陷的新鲜完整人肺叶，穿刺肿瘤体。分别用生理盐水反复冲洗胸膜针孔和穿刺针头。制备冲洗液作为接种体，然后涂抹接种体进行显微镜检查，寻找癌细胞。将接种体皮下接种到裸鼠体内，然后通过得出裸鼠肿瘤发生率，间接得出肺活检后胸膜腔和针道种植转移的概率：结果：胸膜针孔组裸鼠肿瘤发生率为3.3%，穿刺针头组裸鼠肿瘤发生率为3.3%：结论：肺部结节疑似早期癌症且适合手术切除的患者可放弃肺部活检，以避免胸膜腔或针道播散肿瘤细胞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational cancer research ONCOLOGY-

CiteScore

2.10

自引率

0.00%

发文量

252

期刊介绍： Translational Cancer Research (Transl Cancer Res TCR; Print ISSN: 2218-676X; Online ISSN 2219-6803; http://tcr.amegroups.com/) is an Open Access, peer-reviewed journal, indexed in Science Citation Index Expanded (SCIE). TCR publishes laboratory studies of novel therapeutic interventions as well as clinical trials which evaluate new treatment paradigms for cancer; results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of cancer patients. The focus of TCR is original, peer-reviewed, science-based research that successfully advances clinical medicine toward the goal of improving patients'' quality of life. The editors and an international advisory group of scientists and clinician-scientists as well as other experts will hold TCR articles to the high-quality standards. We accept Original Articles as well as Review Articles, Editorials and Brief Articles.