Microplastic exposure linked to accelerated aging and impaired adipogenesis in fat cells.

IF 3.8 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Scientific Reports Pub Date : 2024-10-13 DOI:10.1038/s41598-024-74892-6

Hanbyeol Moon, Damin Jeong, Jung-Won Choi, Seongtae Jeong, Hojin Kim, Byeong-Wook Song, Soyeon Lim, Il-Kwon Kim, Seahyoung Lee, Sang Woo Kim

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引用次数: 0

Abstract

Our research explores the detrimental effects of microplastic (MP) exposure on adipose tissue aging and function, emphasizing the potential health risks associated with environmental pollutants. Utilizing both in vivo and in vitro models, we discovered that MPs accumulate in adipose tissues, leading to cellular senescence, inflammation, and hindered adipogenic differentiation. Notably, our findings demonstrate that MPs prompt an aging response in both epididymal and inguinal white adipose tissue, increase senescence-associated β-galactosidase activity, and upregulate key senescence and inflammatory markers. Furthermore, we show that MPs disrupt normal adipogenic differentiation by reducing lipid droplet formation and downregulating critical adipogenic markers. These insights highlight the urgent need for further investigation into the long-term consequences of MP pollution on biological aging and underscore the importance of developing public health strategies to mitigate these effects.

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接触微塑料与加速衰老和脂肪细胞脂肪生成受损有关。

我们的研究探讨了微塑料（MP）暴露对脂肪组织衰老和功能的有害影响，强调了与环境污染物相关的潜在健康风险。利用体内和体外模型，我们发现微塑料在脂肪组织中积聚，导致细胞衰老、炎症和脂肪分化受阻。值得注意的是，我们的研究结果表明，MPs 会促使附睾和腹股沟白色脂肪组织出现衰老反应，增加衰老相关的 β-半乳糖苷酶活性，并上调关键的衰老和炎症标志物。此外，我们还发现 MPs 通过减少脂滴的形成和下调关键的成脂标志物来破坏正常的成脂分化。这些见解突出表明，迫切需要进一步调查 MP 污染对生物衰老的长期影响，并强调了制定公共卫生策略以减轻这些影响的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Scientific Reports Natural Science Disciplines-

CiteScore

7.50

自引率

4.30%

发文量

19567

审稿时长

3.9 months

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