Comparison between modified and conventional combined Trabeculotomy-Trabeculectomy with Mitomycin-C for intraocular pressure reduction in primary congenital glaucoma.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-01 DOI:10.12669/pjms.40.9.8788

Ahmed Raza, Muhammad Ajmal Chaudhary, Asma Mushtaq, Asad Aslam Khan

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Abstract

Objectives: To determine the efficacy of modified combined trabeculotomy-trabeculectomy (CTT) with mitomycin-C (MMC) versus conventional CTT with MMC for intraocular pressure (IOP) reduction in patients with primary congenital glaucoma (PCG).

Methods: This interventional study was carried out in The Institute of Ophthalmology, Lahore from January 2018 to June 2019. We included 70 patients of either gender, with the age range from birth to ten years and with PCG having IOP >30 mm Hg. These patients were divided in groups A and B with 35 patients in each group. Patients in Group-A underwent modified CTT with MMC and in Group-B conventional CTT with MMC was carried out.

Results: The mean age of our patients was 15.17 ± 12.39 months. Regarding gender, 57 (81.4%) were males and 13 (18.6%) were females. Baseline mean IOP in Group-A was 32.49 ± 1.01 mm Hg whereas in Group-B mean IOP was 31.97 ± 1.04 mm Hg. After one month, the mean IOP was 27.60 ± 1.72 mm Hg in Group-A, whereas mean IOP was 27.40 ± 1.82 mmHg in Group-B. After three months, the mean IOP was 21.63 ± 1.09 mm Hg in Group-A, whereas 20.97 ± 1.12 mm Hg in Group-B. In Group-A efficacy was achieved in 14 (40%) patients whereas in Group-B efficacy was achieved in 25 (71.4%) patients.

Conclusion: Our study revealed that conventional CTT with MMC showed better efficacy than modified CTT with MMC for reduction of IOP in PCG.

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在降低原发性先天性青光眼眼压方面，改良型和传统型小梁切开术-小梁切除术联合丝裂霉素-C疗法的比较。

研究目的确定使用丝裂霉素-C（MMC）的改良联合小梁切开术-小梁切除术（CTT）与使用丝裂霉素-C的传统CTT相比，对原发性先天性青光眼（PCG）患者降低眼压（IOP）的疗效：这项干预研究于 2018 年 1 月至 2019 年 6 月在拉合尔眼科研究所进行。我们纳入了 70 名患者，性别不限，年龄范围从出生到 10 岁，PCG 患者的眼压大于 30 mm Hg。这些患者被分为 A 组和 B 组，每组 35 人。A 组患者接受改良 CTT 和 MMC，B 组患者接受传统 CTT 和 MMC：患者的平均年龄为（15.17 ± 12.39）个月。性别方面，男性 57 人（81.4%），女性 13 人（18.6%）。A 组的基线平均眼压为（32.49 ± 1.01）毫米汞柱，B 组的基线平均眼压为（31.97 ± 1.04）毫米汞柱。一个月后，A 组的平均眼压为（27.60 ± 1.72）毫米汞柱，而 B 组的平均眼压为（27.40 ± 1.82）毫米汞柱。三个月后，A 组的平均眼压为 21.63 ± 1.09 毫米汞柱，而 B 组为 20.97 ± 1.12 毫米汞柱。A组有14名患者（40%）获得了疗效，而B组有25名患者（71.4%）获得了疗效：我们的研究表明，在降低 PCG 患者眼压方面，传统 CTT 联合 MMC 的疗效优于改良 CTT 联合 MMC。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.