Mesenchymal stromal cells as cancer promoters

IF 6.9 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Oncogene Pub Date : 2024-10-16 DOI:10.1038/s41388-024-03183-1

Roula Antoon, Nina Overdevest, Amr H. Saleh, Armand Keating

引用次数: 0

Abstract

Mesenchymal stromal cells (MSCs) are important cellular constituents of tumor stroma that play an active role in tumor development. Complex interactions between MSCs and cancer promote tumor progression by creating a favorable milieu for tumor cell proliferation, angiogenesis, motility, invasion, and metastasis. The cellular heterogeneity, source of origin, diversity in isolation methods, culture techniques and model systems of MSCs, together with the different tumor subtypes, add to the complexity of MSC-tumor interactions. In this review, we discuss the mechanisms of MSC-mediated tumor promotion and evaluate cell-stromal interactions between cancer cells, MSCs, cells of the tumor microenvironment (TME), and the extracellular matrix (ECM). A more thorough understanding of tumor-MSC interactions is likely to lead to better cancer management.

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间充质基质细胞是癌症的促进因素。

间充质基质细胞（MSCs）是肿瘤基质的重要细胞成分，在肿瘤发生发展过程中发挥着积极作用。间充质干细胞与癌症之间复杂的相互作用为肿瘤细胞的增殖、血管生成、运动、侵袭和转移创造了有利的环境，从而促进了肿瘤的发展。间充质干细胞的细胞异质性、来源、分离方法、培养技术和模型系统的多样性，以及不同的肿瘤亚型，增加了间充质干细胞与肿瘤相互作用的复杂性。在这篇综述中，我们讨论了间充质干细胞介导的肿瘤促进机制，并评估了癌细胞、间充质干细胞、肿瘤微环境（TME）细胞和细胞外基质（ECM）之间的细胞间质相互作用。更透彻地了解肿瘤与间充质干细胞之间的相互作用可能有助于更好地治疗癌症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oncogene 医学-生化与分子生物学

CiteScore

15.30

自引率

1.20%

发文量

404

审稿时长

1 months

期刊介绍： Oncogene is dedicated to advancing our understanding of cancer processes through the publication of exceptional research. The journal seeks to disseminate work that challenges conventional theories and contributes to establishing new paradigms in the etio-pathogenesis, diagnosis, treatment, or prevention of cancers. Emphasis is placed on research shedding light on processes driving metastatic spread and providing crucial insights into cancer biology beyond existing knowledge. Areas covered include the cellular and molecular biology of cancer, resistance to cancer therapies, and the development of improved approaches to enhance survival. Oncogene spans the spectrum of cancer biology, from fundamental and theoretical work to translational, applied, and clinical research, including early and late Phase clinical trials, particularly those with biologic and translational endpoints.