Anti-Myelin-Associated Glycoprotein Neuropathy: Recent Developments.

IF 2.3 Q3 CLINICAL NEUROLOGY

Neurology. Clinical practice Pub Date : 2025-02-01 Epub Date: 2024-10-08 DOI:10.1212/CPJ.0000000000200368

Jennifer Morganroth, Chafic Karam

引用次数: 0

Abstract

Background: The purpose of this review is to give an update on myelin-associated glycoprotein (MAG) neuropathy.

Recent findings: There are several recent developments in anti-MAG neuropathy, with the major one being the retrospective analysis of 50 clinical trials that showed that at least a 50% reduction in anti-MAG levels is associated with a therapeutic response. Other updates address antibody levels needed for a positive test, response, and exacerbations to therapy and the type of antibody more associated with malignancy.

Implications for practice: Anti-MAG neuropathy is heterogeneous, and the natural history of the disease continues to be refined. Treatment options are being explored for refractory disease.

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抗髓鞘相关糖蛋白神经病：最新进展。

背景：本综述旨在介绍髓鞘相关糖蛋白（MAG）神经病变的最新进展：抗 MAG 神经病变方面有几项最新进展，其中最主要的是对 50 项临床试验的回顾性分析，分析表明抗 MAG 水平至少降低 50%与治疗反应相关。其他更新还涉及阳性检测所需的抗体水平、对治疗的反应和加重，以及与恶性肿瘤更相关的抗体类型：抗 MAG 神经病变具有异质性，该病的自然史仍在不断完善。目前正在探索针对难治性疾病的治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurology. Clinical practice CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

0.00%

发文量

期刊介绍： Neurology® Genetics is an online open access journal publishing peer-reviewed reports in the field of neurogenetics. The journal publishes original articles in all areas of neurogenetics including rare and common genetic variations, genotype-phenotype correlations, outlier phenotypes as a result of mutations in known disease genes, and genetic variations with a putative link to diseases. Articles include studies reporting on genetic disease risk, pharmacogenomics, and results of gene-based clinical trials (viral, ASO, etc.). Genetically engineered model systems are not a primary focus of Neurology® Genetics, but studies using model systems for treatment trials, including well-powered studies reporting negative results, are welcome.