In Situ Expression of TNF-α and IL-10 in Human Dermatophytosis Lesions due to Trichophyton rubrum.

IF 3.6 3区生物学 Q2 MYCOLOGY

Mycopathologia Pub Date : 2024-10-18 DOI:10.1007/s11046-024-00895-6

Ana Paula Carvalho Reis, Franciele Fernandes Correia, Giovanna Azevedo Celestrino, Carla Pagliari, Paulo Ricardo Criado, Pritesh Jaychand Lalwani, Gil Benard, Maria Gloria Teixeira Sousa

引用次数: 0

Abstract

Dermatophytosis is a very common superficial mycosis, but there are few studies about the human immune response to dermatophytes. We aim to analyze the in situ expression of TNF-α and IL-10 in human dermatophytosis. Expression of TNF-α and IL-10 were evaluated in skin samples from 10 patients with dermatophytosis and 12 healthy subjects using an immunohistochemistry assay. TNF-α and IL-10 were significantly elevated in lesions from patients with dermatophytosis compared to healthy controls. These data illustrate the balance of pro- and anti-inflammatory cytokines suggesting Trichophyton rubrum infection could control the local immune response.

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TNF-α 和 IL-10 在由红色毛癣菌引起的人类皮癣病病变中的原位表达。

皮癣是一种非常常见的浅表真菌病，但有关人类对皮癣菌的免疫反应的研究却很少。我们旨在分析 TNF-α 和 IL-10 在人类皮癣病中的原位表达。我们采用免疫组化法对 10 名皮真菌病患者和 12 名健康人的皮肤样本中 TNF-α 和 IL-10 的表达进行了评估。与健康对照组相比，皮癣患者皮损中的 TNF-α 和 IL-10 明显升高。这些数据说明了促炎和抗炎细胞因子之间的平衡，表明红色毛癣菌感染可控制局部免疫反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mycopathologia 生物-真菌学

CiteScore

6.80

自引率

3.60%

发文量

审稿时长

3 months

期刊介绍： Mycopathologia is an official journal of the International Union of Microbiological Societies (IUMS). Mycopathologia was founded in 1938 with the mission to ‘diffuse the understanding of fungal diseases in man and animals among mycologists’. Many of the milestones discoveries in the field of medical mycology have been communicated through the pages of this journal. Mycopathologia covers a diverse, interdisciplinary range of topics that is unique in breadth and depth. The journal publishes peer-reviewed, original articles highlighting important developments concerning medically important fungi and fungal diseases. The journal highlights important developments in fungal systematics and taxonomy, laboratory diagnosis of fungal infections, antifungal drugs, clinical presentation and treatment, and epidemiology of fungal diseases globally. Timely opinion articles, mini-reviews, and other communications are usually invited at the discretion of the editorial board. Unique case reports highlighting unprecedented progress in the diagnosis and treatment of fungal infections, are published in every issue of the journal. MycopathologiaIMAGE is another regular feature for a brief clinical report of potential interest to a mixed audience of physicians and laboratory scientists. MycopathologiaGENOME is designed for the rapid publication of new genomes of human and animal pathogenic fungi using a checklist-based, standardized format.