Pathogenesis and Systemic treatment of Hepatocellular Carcinoma: Current Status and Prospects.

IF 5.3 2区医学 Q1 ONCOLOGY

Molecular Cancer Therapeutics Pub Date : 2024-10-17 DOI:10.1158/1535-7163.MCT-24-0403

Wanting Lei, Kexun Zhou, Ye Lei, Qiu Li, Hong Zhu

引用次数: 0

Abstract

Hepatocellular carcinoma (HCC) remains one of the major threats to human health worldwide. The emergence of systemic therapeutic options have greatly improved the prognosis of patients with HCC, particularly those with advanced stages of the disease. In this review, we discussed the pathogenesis of HCC, genetic alterations associated with the development of HCC, and alterations in the tumor immune microenvironment. Then, important indicators and emerging technologies related to the diagnosis of HCC are summarized. Also, we reviewed the major advances in treatments for HCC, offering insights into future prospects for next-generation managements.

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肝细胞癌的发病机制和系统治疗：现状与前景。

肝细胞癌（HCC）仍然是全球人类健康的主要威胁之一。系统治疗方案的出现大大改善了 HCC 患者的预后，尤其是晚期患者。在这篇综述中，我们讨论了 HCC 的发病机制、与 HCC 发展相关的基因改变以及肿瘤免疫微环境的改变。然后，总结了与诊断 HCC 相关的重要指标和新兴技术。此外，我们还回顾了治疗 HCC 的主要进展，为下一代治疗方法的未来前景提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cancer Therapeutics 医学-肿瘤学

CiteScore

11.20

自引率

1.80%

发文量

331

审稿时长

3 months

期刊介绍： Molecular Cancer Therapeutics will focus on basic research that has implications for cancer therapeutics in the following areas: Experimental Cancer Therapeutics, Identification of Molecular Targets, Targets for Chemoprevention, New Models, Cancer Chemistry and Drug Discovery, Molecular and Cellular Pharmacology, Molecular Classification of Tumors, and Bioinformatics and Computational Molecular Biology. The journal provides a publication forum for these emerging disciplines that is focused specifically on cancer research. Papers are stringently reviewed and only those that report results of novel, timely, and significant research and meet high standards of scientific merit will be accepted for publication.