The Impact of Genetic Polymorphisms for Detecting Genotoxicity in Workers Occupationally Exposed to Metals: A Systematic Review.

IF 2.7 4区医学 Q3 TOXICOLOGY

Journal of Applied Toxicology Pub Date : 2024-10-21 DOI:10.1002/jat.4711

Thiago Guedes Pinto, Thayza Aires Dias, Ana Claudia Muniz Renno, Jean Nunes Dos Santos, Patrícia Ramos Cury, Daniel Araki Ribeiro

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引用次数: 0

Abstract

The present study aims to provide a systematic review of studies on the essential and nonessential metal exposure at occupational level, genotoxicity, and polymorphisms and to answer the following questions: Are genetic polymorphisms involved in metal-induced genotoxicity? In this study, 14 publications were carefully analyzed in this setting. Our results pointed out an association between polymorphism and genotoxicity in individuals exposed to metals, because 13 studies (out of 14) revealed positive relations between genotoxicity and polymorphisms in xenobiotics metabolizing and DNA repair genes. Regarding the quality of these findings, they can be considered reliable, as the vast majority of the studies (12 out of 14) were categorized as strong or moderate in the quality assessment. Taken as a whole, occupational exposure to metals (essentials or not) induces genotoxicity in peripheral blood or oral mucosa cells. Additionally, professional individuals with certain genotypes may present higher or lower DNA damage as well as DNA repair potential, which will certainly impact the level of DNA damage in the occupational environment.

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基因多态性对检测职业接触金属工人遗传毒性的影响：系统回顾

本研究旨在对有关职业水平的基本金属和非基本金属暴露、遗传毒性和多态性的研究进行系统综述，并回答以下问题：基因多态性是否与金属诱导的遗传毒性有关？在这项研究中，我们仔细分析了 14 篇相关文献。我们的研究结果表明，多态性与暴露于金属的个体的基因毒性之间存在关联，因为（14 项研究中的）13 项研究显示，基因毒性与异种生物代谢基因和 DNA 修复基因的多态性之间存在正相关关系。关于这些研究结果的质量，可以认为是可靠的，因为绝大多数研究（14 项中的 12 项）在质量评估中被归类为强或中等。总的来说，职业性接触金属（无论本质与否）都会诱发外周血或口腔黏膜细胞的基因毒性。此外，具有特定基因型的专业人员可能会出现较高或较低的 DNA 损伤以及 DNA 修复潜能，这必然会影响职业环境中的 DNA 损伤水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Applied Toxicology 医学-毒理学

CiteScore

7.00

自引率

6.10%

发文量

145

审稿时长

1 months

期刊介绍： Journal of Applied Toxicology publishes peer-reviewed original reviews and hypothesis-driven research articles on mechanistic, fundamental and applied research relating to the toxicity of drugs and chemicals at the molecular, cellular, tissue, target organ and whole body level in vivo (by all relevant routes of exposure) and in vitro / ex vivo. All aspects of toxicology are covered (including but not limited to nanotoxicology, genomics and proteomics, teratogenesis, carcinogenesis, mutagenesis, reproductive and endocrine toxicology, toxicopathology, target organ toxicity, systems toxicity (eg immunotoxicity), neurobehavioral toxicology, mechanistic studies, biochemical and molecular toxicology, novel biomarkers, pharmacokinetics/PBPK, risk assessment and environmental health studies) and emphasis is given to papers of clear application to human health, and/or advance mechanistic understanding and/or provide significant contributions and impact to their field.