How condensed are mitotic chromosomes?

IF 7.4 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2024-11-04 Epub Date: 2024-10-14 DOI:10.1083/jcb.202409044

Hide A Konishi, Hironori Funabiki

引用次数: 0

Abstract

Chromosomes undergo dramatic compaction during mitosis, but accurately measuring their volume has been challenging. Employing serial block face scanning electron microscopy, Cisneros-Soberanis et al. (https://doi.org/10.1083/jcb.202403165) report that mitotic chromosomes compact to a nucleosome concentration of ∼760 µM.

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有丝分裂染色体的浓缩程度如何？

染色体在有丝分裂过程中会发生急剧压缩，但准确测量其体积一直是个难题。Cisneros-Soberanis 等人（https://doi.org/10.1083/jcb.202403165）利用序列块面扫描电子显微镜报告说，有丝分裂染色体压实到核小体浓度为 ∼ 760 µM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.