Caenorhabditis elegans as in vivo model for the screening of natural plants-derived novel anti-aging compounds: a short introduction.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-10-15 DOI:10.1080/10286020.2024.2414189

Samah H O Zarroug

引用次数: 0

Abstract

The global aging population highlights the need for effective anti-aging treatments. Natural products show promise, but thorough evaluation requires in vivo models due to the complexity of aging. Ethical concerns are driving a shift from traditional models like rabbits and mice to alternatives such as Caenorhabditis elegans. This microscopic nematode, with its short life cycle, genetic similarities to humans, and cost-effectiveness, is ideal for testing anti-aging compounds. We review studies using C. elegans to assess natural products, suggesting it could serve as a primary model for -evaluating the safety and efficacy of plant-derived anti-aging compounds.

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作为体内模型筛选天然植物提取的新型抗衰老化合物的草履虫：简短介绍。

全球人口老龄化凸显了对有效抗衰老疗法的需求。天然产品大有可为，但由于衰老的复杂性，彻底评估需要体内模型。出于伦理方面的考虑，人们正在从兔子和小鼠等传统模型向 elegans 线虫等替代模型转变。这种微小的线虫生命周期短，基因与人类相似，成本效益高，是测试抗衰老化合物的理想选择。我们回顾了利用秀丽隐杆线虫评估天然产品的研究，认为它可以作为评估植物抗衰老化合物安全性和有效性的主要模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.