Understanding necrotizing enterocolitis endotypes and acquired intestinal injury phenotypes from a historical and artificial intelligence perspective.

IF 2.1 3区医学 Q2 PEDIATRICS

Frontiers in Pediatrics Pub Date : 2024-09-27 eCollection Date: 2024-01-01 DOI:10.3389/fped.2024.1432808

Alain Cuna, Navin Kumar, Venkatesh Sampath

引用次数: 0

Abstract

Necrotizing enterocolitis (NEC) remains a devastating disease in preterm and term neonates. Despite significant progress made in understanding NEC pathogenesis over the last 50 years, the inability of current definitions to discriminate the various pathophysiological processes underlying NEC has led to an umbrella term that limits clinical and research progress. In this mini review, we provide a historical perspective on how NEC definitions and pathogenesis have evolved to our current understanding of NEC endotypes. We also discuss how artificial intelligence-based approaches are influencing our knowledge of risk-factors, classification and prognosis of NEC and other neonatal intestinal injury phenotypes.

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从历史和人工智能的角度理解坏死性小肠结肠炎内型和获得性肠损伤表型。

坏死性小肠结肠炎（NEC）仍然是早产儿和足月新生儿的一种毁灭性疾病。尽管在过去的 50 年中，人们在了解 NEC 发病机制方面取得了重大进展，但由于目前的定义无法区分 NEC 的各种病理生理过程，因此形成了一个限制临床和研究进展的总称。在这篇小型综述中，我们从历史的角度阐述了 NEC 定义和发病机制是如何演变到我们目前对 NEC 内型的理解的。我们还将讨论基于人工智能的方法如何影响我们对 NEC 和其他新生儿肠道损伤表型的风险因素、分类和预后的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Pediatrics Medicine-Pediatrics, Perinatology and Child Health

CiteScore

3.60

自引率

7.70%

发文量

2132

审稿时长

14 weeks

期刊介绍： Frontiers in Pediatrics (Impact Factor 2.33) publishes rigorously peer-reviewed research broadly across the field, from basic to clinical research that meets ongoing challenges in pediatric patient care and child health. Field Chief Editors Arjan Te Pas at Leiden University and Michael L. Moritz at the Children''s Hospital of Pittsburgh are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Pediatrics also features Research Topics, Frontiers special theme-focused issues managed by Guest Associate Editors, addressing important areas in pediatrics. In this fashion, Frontiers serves as an outlet to publish the broadest aspects of pediatrics in both basic and clinical research, including high-quality reviews, case reports, editorials and commentaries related to all aspects of pediatrics.