Effects of glucagon-like peptide-1 receptor agonists on endoscopy outcomes: systematic review and meta-analysis

IF 6.7 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gastrointestinal endoscopy Pub Date : 2025-02-01 DOI:10.1016/j.gie.2024.10.011

Sahib Singh MD , Syed Hamaad Rahman DO , Nihal Khan MD , Anjali Rajagopal MD , Nouman Shafique MD , Poonam Tawde MD , Vaishali Bhardwaj MD , Vishnu Charan Suresh Kumar MD , Ganesh Aswath MD , Sumant Inamdar MD , Sudhir Dutta MD , Abu Hurairah MD , Babu P. Mohan MD

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引用次数: 0

Abstract

Background and Aims

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are known to cause delayed gastric emptying; however, the effect on clinical outcomes during upper endoscopy and colonoscopy remains unclear. We conducted a meta-analysis to reconcile the data.

Methods

Online databases were searched for studies evaluating GLP-1RAs versus a control group (no GLP-1RAs) in patients undergoing endoscopy. The outcomes of interest were rate of retained gastric contents (RGCs), aborted procedures, aspiration events, and subjective bowel preparation quality. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using a random-effects model.

Results

Twenty-three studies with 77,152 patients (4449 in the GLP-1RA arm and 72,703 in the control arm) were included. Mean patient age ranged from 47.6 to 72 years, and 58.4% were women. As compared with the control group, the GLP-1RA group had higher odds of RGCs (OR, 15.39; 95% CI, 4.65-50.99; P < .01) and aborted procedures (OR, 13.86; 95% CI, 4.42-43.43; P < .01). No significant differences were observed between the 2 groups in terms of aspiration events (OR, 21.06; 95% CI, .13-3379.01; P = .24) and subjective bowel preparation quality (OR, .94; 95% CI, .67-1.31; P = .83).

Conclusions

Although statistical significance was reached in terms of visible RGCs and early termination of endoscopies in patients on GLP-1RAs, these events were overall rare. GLP-1RAs do not appear to pose significant risk, as the odds of developing aspiration were comparable in the 2 groups.

查看原文本刊更多论文

胰高血糖素样肽-1 受体激动剂对内镜检查结果的影响：系统回顾与荟萃分析。

背景和目的：众所周知，胰高血糖素样肽-1受体激动剂（GLP-1RAs）可导致胃排空延迟，但其对上内镜/结肠镜检查临床结果的影响仍不明确。我们进行了一项荟萃分析，以核对相关数据：我们在在线数据库中搜索了对接受内镜检查的患者进行评估的研究，评估对象为 GLP-1RAs 与对照组（无 GLP-1RAs）。研究结果包括胃内容物残留率（RGC）、手术流产率、吸入事件和主观肠道准备质量。采用随机效应模型估算了汇总的几率比（ORs）和95%置信区间（CIs）：共有 23 项研究纳入了 77,271 名患者（GLP-1 RA 组 4,449 人，对照组 72,703 人）。平均年龄从 47.6 岁到 72 岁不等，58.4% 为女性。与对照组相比，GLP-1 RA 组发生 RGC（OR 15.39，95% CI 4.65-50.99，p < 0.01）和流产（OR 13.86，95% CI 4.42-43.43，p < 0.01）的几率更高。在吸入事件（OR 21.06，95% CI 0.13-3379.01，P=0.24）和主观肠道准备质量（OR 0.94，95% CI 0.67-1.31，P=0.83）方面，两组间未观察到明显差异：虽然在使用 GLP-1RAs 的患者中，可见 RGC 和提前终止内镜检查的情况具有统计学意义，但这些事件总体上很少发生。GLP-1RA似乎不会带来重大风险，因为两组患者发生吸入的几率相当。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastrointestinal endoscopy 医学-胃肠肝病学

CiteScore

10.30

自引率

7.80%

发文量

1441

审稿时长

38 days

期刊介绍： Gastrointestinal Endoscopy is a journal publishing original, peer-reviewed articles on endoscopic procedures for studying, diagnosing, and treating digestive diseases. It covers outcomes research, prospective studies, and controlled trials of new endoscopic instruments and treatment methods. The online features include full-text articles, video and audio clips, and MEDLINE links. The journal serves as an international forum for the latest developments in the specialty, offering challenging reports from authorities worldwide. It also publishes abstracts of significant articles from other clinical publications, accompanied by expert commentaries.