Using oral topiramate for primary generalized and focal-to-bilateral tonic-clonic seizures in patients 2 years of age and older: a review of the literature.

IF 3.4 2区 医学 Q2 CLINICAL NEUROLOGY
Slobodan M Janković, Dobrivoje Stojadinović, Vera Dabanović
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Abstract

Introduction: Topiramate is a drug belonging to the second generation of antiseizure arsenal, used to treat focal onset seizures without generalization, focal-to-bilateral tonic-clonic seizures, and primary generalized tonic-clonic seizures.

Areas covered: The narrative evaluation of topiramate's clinical research that has been published in this article focuses on the medication's effectiveness and safety when used to treat primary generalized and focal-to-bilateral tonic-clonic seizures. From their founding to the present, the databases MEDLINE, SCOPUS, EBSCO, and GOOGLE SCHOLAR were searched.

Expert opinion: Topiramate treatment has the obvious benefit of being effective in treating tonic-clonic seizures; nevertheless, it may have a drawback in that up to 56% of patients discontinue therapy due to its rather poor tolerability, particularly at doses exceeding 600 mg daily. Patients are most bothered by psychiatric and cognitive side effects, and then by appetite and weight decrease. While the onset of anorexia cannot be prevented by changing the dosage regimen, psychiatric and cognitive side effects can be mitigated by slowly titrating the topiramate dose.

使用口服托吡酯治疗 2 岁及以上患者的原发性全身强直阵挛发作和局灶至双侧强直阵挛发作:文献综述。
简介托吡酯是一种属于第二代抗癫痫药物库的药物,用于治疗无全身化的局灶性发作、局灶-双侧强直-阵挛发作和原发性全身强直-阵挛发作:本文发表的对托吡酯临床研究的叙述性评估侧重于该药物用于治疗原发性全身性和局灶对双侧强直阵挛发作时的有效性和安全性。从创立至今,我们检索了 MEDLINE、SCOPUS、EBSCO 和 GOOGLE SCHOLAR 等数据库:托吡酯治疗的明显优点是能有效治疗强直-阵挛发作;但它也有缺点,即由于耐受性较差,尤其是每日剂量超过 600 毫克时,多达 56% 的患者会中断治疗。患者最担心的是精神和认知方面的副作用,其次是食欲和体重下降。虽然无法通过改变剂量方案来预防厌食症的发生,但可以通过缓慢滴定托吡酯的剂量来减轻精神和认知方面的副作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Expert Review of Neurotherapeutics
Expert Review of Neurotherapeutics Medicine-Neurology (clinical)
CiteScore
7.00
自引率
2.30%
发文量
61
审稿时长
4-8 weeks
期刊介绍: Expert Review of Neurotherapeutics (ISSN 1473-7175) provides expert reviews on the use of drugs and medicines in clinical neurology and neuropsychiatry. Coverage includes disease management, new medicines and drugs in neurology, therapeutic indications, diagnostics, medical treatment guidelines and neurological diseases such as stroke, epilepsy, Alzheimer''s and Parkinson''s. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points
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