The role of dietary inflammatory index in metabolic diseases: the associations, mechanisms, and treatments.

IF 3.6 3区 医学 Q2 NUTRITION & DIETETICS
Jialu Xu, Lei Xie, Rongping Fan, Xiaoli Shi, Weijie Xu, Kun Dong, Delin Ma, Yongli Yan, Shujun Zhang, Nan Sun, Guomin Huang, Min Gao, Xuefeng Yu, Mei Wang, Fen Wang, Juan Chen, Jing Tao, Yan Yang
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引用次数: 0

Abstract

In recent years, the prevalence of metabolic diseases has increased significantly, posing a serious threat to global health. Chronic low-grade inflammation is implicated in the development of most metabolic diseases, such as type 2 diabetes mellitus (T2DM), obesity, dyslipidemia, and cardiovascular disease, serving as a link between diet and these conditions. Increasing attention has been directly toward dietary inflammatory patterns that may prevent or ameliorate metabolic diseases. The Dietary Inflammatory Index (DII) was developed to assess the inflammatory potential of dietary intake. Consequently, a growing body of research has examined the associations between the DII and the risk of several metabolic diseases. In this review, we explore the current scientific literature on the relationships between the DII, T2DM, obesity, and dyslipidemia. It summarizes recent findings and explore potential underlying mechanisms from two aspects: the interaction between diet and inflammation, and the link between inflammation and metabolic diseases. Furthermore, this review discusses the therapeutic strategies, including dietary modifications, prebiotics, and probiotics, and discusses the application of the DII in metabolic diseases, as well as future research directions.

饮食炎症指数在代谢性疾病中的作用:关联、机制和治疗方法。
近年来,代谢性疾病的发病率大幅上升,对全球健康构成严重威胁。慢性低度炎症与大多数代谢性疾病(如 2 型糖尿病(T2DM)、肥胖症、血脂异常和心血管疾病)的发病有关,是饮食与这些疾病之间的联系纽带。人们越来越关注可预防或改善代谢性疾病的膳食炎症模式。膳食炎症指数(DII)就是为了评估膳食摄入的炎症潜力而开发的。因此,越来越多的研究探讨了膳食炎症指数与多种代谢性疾病风险之间的关系。在这篇综述中,我们探讨了目前有关 DII、T2DM、肥胖和血脂异常之间关系的科学文献。它总结了最近的研究结果,并从两个方面探讨了潜在的内在机制:饮食与炎症之间的相互作用,以及炎症与代谢性疾病之间的联系。此外,本综述还讨论了包括饮食调整、益生元和益生菌在内的治疗策略,并探讨了 DII 在代谢性疾病中的应用以及未来的研究方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
10.60
自引率
2.10%
发文量
189
审稿时长
3-6 weeks
期刊介绍: The European Journal of Clinical Nutrition (EJCN) is an international, peer-reviewed journal covering all aspects of human and clinical nutrition. The journal welcomes original research, reviews, case reports and brief communications based on clinical, metabolic and epidemiological studies that describe methodologies, mechanisms, associations and benefits of nutritional interventions for clinical disease and health promotion. Topics of interest include but are not limited to: Nutrition and Health (including climate and ecological aspects) Metabolism & Metabolomics Genomics and personalized strategies in nutrition Nutrition during the early life cycle Health issues and nutrition in the elderly Phenotyping in clinical nutrition Nutrition in acute and chronic diseases The double burden of ''malnutrition'': Under-nutrition and Obesity Prevention of Non Communicable Diseases (NCD)
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