Effectiveness of bariatric surgery on acquired hypothalamic obesity: a systematic review and meta-analysis.

IF 2.6 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Endocrine Connections Pub Date : 2024-11-26 Print Date: 2024-12-01 DOI:10.1530/EC-24-0493

Muyang He, Haijia Xu, Zhen Ying, Ying Chen, XiaoYing Li

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Abstract

Acquired hypothalamic obesity (HO) is a rare type of obesity caused by acquired disease-related and/or treatment-related damage to the hypothalamus, most commonly craniopharyngiomas. Effective management of HO is critical due to its significant impact on quality of life and resistance to conventional treatments. This systematic review and meta-analysis aims to evaluate the 12-month, 24-month and 60-month outcomes of bariatric surgery for HO caused by CPs compared with patients with common obesity (CO). Relevant studies were identified in MEDLINE and EMBASE databases until May 2024. A total of four matched case-control studies were included. The results indicated that bariatric surgery significantly reduced weight in patients with HO (22.98 ± 14.22/21.47 ± 9.61/19.07 ± 16.12% total weight loss, 12/24/60 months after surgery), but the effect was significantly less than that in CO controls (-6.17/-6.41/-7.72% total weight loss 12/24/60 months after surgery). Bariatric surgery can significantly reduce body weight in craniopharyngiomas-related HO, but the effect is less than that in matched patients with common obesity. Further studies are necessary to determine the best surgical or multidisciplinary approach to the treatment of acquired HO.

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减肥手术对获得性下丘脑肥胖症的疗效：系统回顾和荟萃分析。

获得性下丘脑肥胖症（HO）是一种罕见的肥胖症，是由于下丘脑（最常见的是颅咽管瘤）后天受到疾病和/或治疗相关的损伤所致。由于下丘脑性肥胖对生活质量有重大影响，且对常规治疗有耐药性，因此有效治疗下丘脑性肥胖至关重要。本系统综述和荟萃分析旨在评估与普通肥胖症（CO）患者相比，肥胖症手术治疗 CP 引起的 HO 的 12 个月、24 个月和 60 个月疗效。相关研究均在MEDLINE和EMBASE数据库中找到，截止日期为2024年5月。共纳入了 4 项匹配病例对照研究。结果表明，减肥手术能显著减轻下丘脑肥胖症患者的体重（术后12/24/60个月，总体重减轻22.98±14.22/21.47±9.61/19.07±16.12%），但效果明显低于普通肥胖症对照组（术后12/24/60个月，总体重减轻-6.17/-6.41/-7.72%）。减肥手术可明显减轻颅咽管瘤相关下丘脑肥胖症患者的体重，但效果不如普通肥胖症对照组患者。要确定治疗获得性下丘脑肥胖症的最佳手术或多学科方法，还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine Connections Medicine-Internal Medicine

CiteScore

5.00

自引率

3.40%

发文量

361

审稿时长

6 weeks

期刊介绍： Endocrine Connections publishes original quality research and reviews in all areas of endocrinology, including papers that deal with non-classical tissues as source or targets of hormones and endocrine papers that have relevance to endocrine-related and intersecting disciplines and the wider biomedical community.